A simple mechanical device reduces subglottic injury in ventilated animals

Objectives/Hypothesis To test whether a simple inexpensive device that dynamically minimizes endotracheal cuff pressure throughout the respiratory cycle reduces endotracheal cuff pressure‐related subglottic injury. Study Design Hypoxic animal model with one control and one experimental group. Method...

Full description

Saved in:
Bibliographic Details
Published in:The Laryngoscope 2013-11, Vol.123 (11), p.2742-2748
Main Authors: Osborn, Alexander J., Chami, Rose, Propst, Evan J., Luginbuehl, Igor, Taylor, Glenn, Fisher, Joseph A., Forte, Vito
Format: Article
Language:English
Subjects:
airway injury
Animals
cuff pressure modulation
Endotracheal tube
Equipment Design
Glottis - injuries
Intubation, Intratracheal - adverse effects
Medical equipment
Neonatal care
Patients
Respiration, Artificial - instrumentation
Swine
Wounds and Injuries - prevention & control
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives/Hypothesis To test whether a simple inexpensive device that dynamically minimizes endotracheal cuff pressure throughout the respiratory cycle reduces endotracheal cuff pressure‐related subglottic injury. Study Design Hypoxic animal model with one control and one experimental group. Methods Twelve S. scrofa domesticus piglets (14–16kg) were intubated with standard endotracheal tubes and maintained in a hypoxic state to accelerate airway injury. Animals in the control group (n = 6) were ventilated with a constant pressure of 20 cm H2O in the endotracheal tube cuff. Animals in the experimental group (n = 6) were ventilated using a custom‐designed circuit that altered the pressure in the endotracheal tube cuff in synchrony with the ventilatory cycle. Larynges were harvested at the end of the experiment and examined histologically to determine the degree of airway injury induced by the endotracheal cuff. Results Animals in the experimental group suffered significantly less airway damage than those in the control group. The differences were seen primarily in the subglottis (aggregate damage score 6.5 vs. 12, P
ISSN:0023-852X
1531-4995
DOI:10.1002/lary.24069