Cells at Risk for Dosimetric Modelling Relevant to Bone Tumour Induction

The assessment of the risk of bone tumour induction from bone seeking radionuclides deposited in the skeleton is normally based on the calculation of doses to sensitive cells located within 10 µm of endosteal bone surfaces. Since the development of the ICRP dosimetric model for the skeleton further...

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Bibliographic Details
Published in:Radiation protection dosimetry 2000-11, Vol.92 (1-3), p.209-213
Main Authors: Gössner, W., Masse, R., Stather (INVITED), J.W.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biological effects of radiation
Diseases of the osteoarticular system
Fundamental and applied biological sciences. Psychology
Ionizing radiations
Medical sciences
Tissues, organs and organisms biophysics
Tumors of striated muscle and skeleton
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Summary:The assessment of the risk of bone tumour induction from bone seeking radionuclides deposited in the skeleton is normally based on the calculation of doses to sensitive cells located within 10 µm of endosteal bone surfaces. Since the development of the ICRP dosimetric model for the skeleton further information has become available on the cells involved in the induction of radiation-induced bone tumours. Present evidence suggests multipotent and totipotent mesenchymal precursors located at a distance from the bone surface are the most likely target cells for the induction of bone tumours. Assessing the exact distance at which these cells are located is beyond the possibility of histological analysis up to now. This will, however, extend beyond the 10 µm layer.
ISSN:0144-8420
1742-3406
DOI:10.1093/oxfordjournals.rpd.a033271