Subsequent malignancies and their effect on survival in patients with retinoblastoma

Background As cure rates for retinoblastoma have improved, it is clear that patients with hereditary retinoblastoma experience increased risk of subsequent malignant neoplasms (SMNs). Methods Using the Surveillance, Epidemiology and End Results (SEER) database, we evaluated risk of SMNs in survivors...

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Bibliographic Details
Published in:Pediatric blood & cancer 2014-01, Vol.61 (1), p.116-119
Main Authors: Shinohara, Eric T., DeWees, Todd, Perkins, Stephanie M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Child, Preschool
Female
Hematology
Humans
Incidence
Kaplan-Meier Estimate
Male
Neoplasms, Second Primary - epidemiology
Neoplasms, Second Primary - etiology
Oncology
Pediatrics
Radiotherapy - adverse effects
Radiotherapy - trends
Retinal Neoplasms - complications
Retinal Neoplasms - mortality
Retinal Neoplasms - radiotherapy
retinoblastoma
Retinoblastoma - complications
Retinoblastoma - mortality
Retinoblastoma - radiotherapy
secondary malignancy
SEER
SEER Program
United States - epidemiology
Young Adult
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Summary:Background As cure rates for retinoblastoma have improved, it is clear that patients with hereditary retinoblastoma experience increased risk of subsequent malignant neoplasms (SMNs). Methods Using the Surveillance, Epidemiology and End Results (SEER) database, we evaluated risk of SMNs in survivors or retinoblastoma. Standardized mortality ratios (SMRs) were calculated to compare number of deaths observed to the expected number for the cohort. Cumulative incidence of SMNs and standardized incidence ratios (SIRs) of observed to expected SMNs were calculated Results A total of 595 patients were included in the analysis. Cumulative incidence of secondary malignancy at 30 years for patients with unilateral and bilateral disease was 1.7% and 28.5%, respectively (P 
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.24714