Chronic rhinosinusitis in asthma is a negative predictor of quality of life: results from the Swedish GA2LEN survey

Background Asthma and chronic rhinosinusitis (CRS) both impair quality of life, but the quality‐of‐life impact of comorbid asthma and CRS is poorly known. The aim of this study was to evaluate the impact of CRS and other relevant factors on quality of life in asthmatic subjects. Methods This Swedish...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2013-10, Vol.68 (10), p.1314-1321
Main Authors: Ek, A., Middelveld, R. J. M., Bertilsson, H., Bjerg, A., Ekerljung, L., Malinovschi, A., Stjärne, P., Larsson, K., Dahlén, S.‐E., Janson, C.
Format: Article
Language:English
Subjects:
Age
Asthma
chronic rhinosinusitis
Comorbidity
lung function
Quality of life
rhinitis
Sinuses
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Summary:Background Asthma and chronic rhinosinusitis (CRS) both impair quality of life, but the quality‐of‐life impact of comorbid asthma and CRS is poorly known. The aim of this study was to evaluate the impact of CRS and other relevant factors on quality of life in asthmatic subjects. Methods This Swedish cohort (age 17–76 years) consists of 605 well‐characterized asthmatics with and without CRS, 110 individuals with CRS only, and 226 controls and is part of the Global Allergy and Asthma European Network (GA2LEN) survey. The Mini Asthma Quality of Life Questionnaire (mAQLQ), the Euro Quality of Life (EQ‐5D) health questionnaire, spirometry, skin prick test (SPT), exhaled nitric oxide (FeNO), smell test, and peak nasal inspiratory flow were used. Results Subjects having both asthma and CRS have lower mAQLQ scores in all domains (P 
ISSN:0105-4538
1398-9995
DOI:10.1111/all.12222