Inhibition of protein synthesis or mTOR in the basolateral amygdala blocks retrieval-induced memory strengthening

Fear memory retrieval can lead to either reconsolidation (accompanied or not by strengthening of the memory trace) or extinction. Here, we show that non-reinforced retrieval of inhibitory avoidance (IA) conditioning can induce memory strengthening assessed in a subsequent retention test trial. Infus...

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Bibliographic Details
Published in:Journal of Neural Transmission 2013-11, Vol.120 (11), p.1525-1531
Main Authors: Pedroso, Thiago R., Jobim, Paulo F. C., Carvalho, Leonardo M., Christoff, Raissa R., Maurmann, Natasha, Reolon, Gustavo K., Werenicz, Aline, Roesler, Rafael
Format: Article
Language:English
Subjects:
Amygdala - drug effects
Amygdala - metabolism
Animals
Avoidance Learning - drug effects
Avoidance Learning - physiology
Conditioning, Classical - drug effects
Conditioning, Classical - physiology
Cycloheximide - pharmacology
Extinction, Psychological - drug effects
Extinction, Psychological - physiology
Fear - drug effects
Fear - physiology
Male
Medicine
Medicine & Public Health
Memory - drug effects
Memory - physiology
Neurology
Neurosciences
Protein Biosynthesis - drug effects
Protein Synthesis Inhibitors - pharmacology
Psychiatry
Rats
Rats, Wistar
Sirolimus - pharmacology
TOR Serine-Threonine Kinases - antagonists & inhibitors
Translational Neurosciences - Original Article
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Summary:Fear memory retrieval can lead to either reconsolidation (accompanied or not by strengthening of the memory trace) or extinction. Here, we show that non-reinforced retrieval of inhibitory avoidance (IA) conditioning can induce memory strengthening assessed in a subsequent retention test trial. Infusion of the protein synthesis inhibitor cycloheximide or the mTOR inhibitor rapamycin into the rat basolateral complex of the amygdala (BLA) after a reactivation (retrieval) session impaired retrieval-induced strengthening. Intra-BLA infusion of the mRNA synthesis inhibitor 5,6-dichloro-1-beta- d -ribofuranosylbenzimidazole (DRB) after retrieval had no effect. These findings provide the first evidence suggesting that non-reinforced IA retrieval can lead to memory strengthening through a mechanism dependent on protein synthesis and mTOR activity in the BLA.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-013-1032-y