A new rapid test for fecal calprotectin predicts endoscopic remission and postoperative recurrence in Crohn's disease

Fecal calprotectin (FC), as determined by the enzyme-linked immunoassay (ELISA) test, has been proposed as a promising biomarker of endoscopic activity in Crohn's disease (CD). However data on its accuracy in predicting endoscopic remission according to location and postoperative recurrence (PO...

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Bibliographic Details
Published in:Journal of Crohn's and colitis 2013-12, Vol.7 (12), p.e641-e651
Main Authors: Lobatón, Triana, López-García, Alicia, Rodríguez-Moranta, Francisco, Ruiz, Alexandra, Rodríguez, Lorena, Guardiola, Jordi
Format: Article
Language:English
Subjects:
Adult
Biomarkers - analysis
C-Reactive Protein - metabolism
Colon - pathology
Colon - surgery
Colonoscopy - utilization
Crohn Disease - metabolism
Crohn Disease - pathology
Crohn Disease - surgery
Crohn's disease
Endoscopic activity
Enzyme-Linked Immunosorbent Assay
Fecal calprotectin
Feces - chemistry
Female
Humans
Ileum - pathology
Ileum - surgery
Leukocyte L1 Antigen Complex - analysis
Male
Middle Aged
Point-of-Care Systems
Postoperative Period
Predictive Value of Tests
Recurrence
Severity of Illness Index
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Summary:Fecal calprotectin (FC), as determined by the enzyme-linked immunoassay (ELISA) test, has been proposed as a promising biomarker of endoscopic activity in Crohn's disease (CD). However data on its accuracy in predicting endoscopic remission according to location and postoperative recurrence (POR) is scarce. Our objective was to evaluate the ability of FC determined by a new quantitative point-of-care test (FC-QPOCT) to predict endoscopic remission and POR in CD patients. FC was determined simultaneously by an enzyme-linked immunoassay test (FC-ELISA) and a FC-QPOCT in CD patients undergoing colonoscopy. Clinical disease activity was assessed according to the Crohn's Disease Activity Index (CDAI). Endoscopic results were assessed according to the Crohn's Disease Endoscopic Activity Index of Severity (CDEIS) and postoperative recurrence according to the Rutgeerts' score. A total of 115 ileocolonoscopies were performed (29 on patients with ileocolonic resection). FC levels correlated more closely with the CDEIS than leucocytes, platelets or CRP. The prediction of “endoscopic remission” (CDEIS
ISSN:1873-9946
1876-4479
DOI:10.1016/j.crohns.2013.05.005