Inhibition of protein glycation by procyanidin‐B2 enriched fraction of cinnamon: Delay of diabetic cataract in rats

Accumulation of advanced glycation endproducts (AGE) from nonenzymatic glycation of proteins has been implicated in several diabetic complications including diabetic cataract. Previously, we have reported that extracts of dietary agents such as cinnamon have the potential to inhibit AGE formation. I...

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Bibliographic Details
Published in:IUBMB life 2013-11, Vol.65 (11), p.941-950
Main Authors: Muthenna, Puppala, Raghu, Ganugula, Akileshwari, Chandrasekhar, Sinha, Sukesh Narayana, Suryanarayana, Palla, Reddy, Geereddy Bhanuprakash
Format: Article
Language:English
Subjects:
advanced glycation end products
Animals
Biflavonoids - therapeutic use
Blood Glucose - metabolism
Cataract - prevention & control
Catechin - therapeutic use
Cinnamomum zeylanicum - chemistry
cinnamon
Diabetes Complications - prevention & control
Diabetes Mellitus, Experimental
diabetic cataract
Glycated Hemoglobin A - antagonists & inhibitors
Glycation End Products, Advanced - antagonists & inhibitors
Glycosylation
Humans
lens proteins
Lens, Crystalline - metabolism
Male
Plant Extracts - therapeutic use
Proanthocyanidins - therapeutic use
procyanidin‐B2
protein glycation
Rats
Rats, Wistar
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Summary:Accumulation of advanced glycation endproducts (AGE) from nonenzymatic glycation of proteins has been implicated in several diabetic complications including diabetic cataract. Previously, we have reported that extracts of dietary agents such as cinnamon have the potential to inhibit AGE formation. In this study, we have shown procyanidin‐B2 as the active component of cinnamon that is involved in AGE inhibition using bioassay‐guided fractionation of eye lens proteins under in vitro conditions. The data indicate that procyanidin‐B2 enriched fraction scavenges dicarbonyls. Further, procyanidin‐B2 fraction of cinnamon inhibited the formation of glycosylated hemoglobin in human blood under ex vivo conditions. We have also demonstrated the physiological significance of procyanidin‐B2 fraction in terms of delay of diabetic cataract through inhibition of AGE in diabetic rats. These findings establish the antiglycating potential of procyanidin‐B2 fraction of cinnamon which suggests a scope for controlling AGE‐mediated diabetic complications by food sources that are rich in proanthocyanidins like procyanidin‐B2. © 2013 IUBMB Life, 65(11):941–950, 2013
ISSN:1521-6543
1521-6551
DOI:10.1002/iub.1214