Obesity Modulates the Immune Response to Oxidized LDL in Hypertensive Patients

Obesity and hypertension have been recognized as inflammatory diseases capable of activating the immune system, thus contributing to an increased cardiovascular risk. However, the link between adaptive immunity, obesity, and hypertension is poorly understood. We investigated the relationship of the...

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Bibliographic Details
Published in:Cell biochemistry and biophysics 2013-12, Vol.67 (3), p.1451-1460
Main Authors: Fonseca, Henrique Andrade R., Fonseca, Francisco A., Monteiro, Andrea M., Bianco, Henrique T., Boschcov, Paulo, Brandão, Sergio A., Juliano, Luiz, Gidlund, Magnus, Izar, Maria C.
Format: Article
Language:English
Subjects:
Adult
Aged
Antihypertensive Agents - therapeutic use
Apolipoproteins B - immunology
Apolipoproteins D - immunology
Autoantibodies - blood
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biotechnology
Blood Pressure
Body Mass Index
Cell Biology
Female
Health risks
Humans
Hypertension
Hypertension - complications
Hypertension - drug therapy
Hypertension - immunology
Immune response
Immune system
Interleukin-10 - blood
Interleukin-8 - blood
Life Sciences
Lipid Peroxidation
Lipoproteins, LDL - immunology
Male
Middle Aged
Monitoring, Ambulatory
Obesity
Obesity - complications
Obesity - immunology
Obesity - metabolism
Pharmacology/Toxicology
Translational Biomedical Research
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Summary:Obesity and hypertension have been recognized as inflammatory diseases capable of activating the immune system, thus contributing to an increased cardiovascular risk. However, the link between adaptive immunity, obesity, and hypertension is poorly understood. We investigated the relationship of the body mass index (BMI) on the inflammatory, vascular, and immune responses in patients with hypertension naïve of anti-hypertensive treatment. Hypertensive patients ( N  = 88) were divided into three groups: normal weight (NW), overweight (OW), and obese (OB) subjects. Anti-oxidized LDL autoantibodies (anti-oxLDL Abs), anti-ApoB-D peptide (anti-ApoB-D) Abs, interleukin (IL)-8 and IL-10, flow-mediated dilation (FMD) of the brachial artery, and 24-h ambulatory blood pressure monitoring (ABPM) were assessed. OB patients presented lower levels of anti-oxLDL Abs and IL-10, higher levels of IL-8, and impaired FMD, when compared to NW and OW ( P  
ISSN:1085-9195
1559-0283
DOI:10.1007/s12013-013-9585-9