Toll-Like Receptor Induced Pro-Interleukin-1 beta and Interleukin-6 in Monocytes Are Lower in Healthy Infants Compared to Adults: e78018

Infants have long been known to have higher infectious diseases morbidity and mortality and suboptimal vaccination responses compared to older children and adults. A variety of differences in innate and adaptive immune responses have been described between these two groups. We compared Toll-like rec...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2013-10, Vol.8 (10)
Main Authors: Libraty, Daniel H, Zhang, Lei, Woda, Marcia, Acosta, Luz P, Obcena, AnaMae, Brion, Job D, Capeding, Rosario Z
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Infants have long been known to have higher infectious diseases morbidity and mortality and suboptimal vaccination responses compared to older children and adults. A variety of differences in innate and adaptive immune responses have been described between these two groups. We compared Toll-like receptor (TLR)-induced production of pro-interleukin (IL)-1 beta , IL-6, and tumor necrosis factor (TNF)- alpha between 2-month-old infants and adults. TLR 7/8-induced production of pro-IL-1 beta and IL-6 in monocytes was lower in 2-month-old infants compared to adults. There was no difference in TLR 7/8-induced production of TNF- alpha . Lower TLR-induced production of pro-IL-1 beta and IL-6 in innate immune cells during early infancy likely contributes to suboptimal vaccine responses and infectious diseases susceptibility.
ISSN:1932-6203
DOI:10.1371/journal.pone.0078018