Congenital Cytomegalovirus Infection: An Obstetrician's Point of View

Maternal cytomegalovirus (CMV) is the cause of the most frequent congenital infection in America; however, pregnant women are not routinely screened. Primary CMV infection is associated with a high maternalto-child transmission rate (40%); up to 15% of these infected neonates will be symptomatic at...

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Bibliographic Details
Published in:Clinical infectious diseases 2013-12, Vol.57 (suppl 4), p.S171-S173
Main Author: Soper, David E.
Format: Article
Language:English
Subjects:
Children
Congenital diseases
Congenital infection
Cytomegalovirus
Cytomegalovirus infections
Cytomegalovirus Infections - diagnosis
Cytomegalovirus Infections - transmission
Cytomegalovirus Infections - virology
Disease transmission
Epidemiology
Female
Humans
Infant, Newborn
Infections
Infectious Disease Transmission, Vertical
Medical screening
Morbidity
Neonates
Nervous system
Pregnancy
Pregnancy Complications, Infectious - virology
Prenatal Diagnosis
Viral diseases
Viruses
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Summary:Maternal cytomegalovirus (CMV) is the cause of the most frequent congenital infection in America; however, pregnant women are not routinely screened. Primary CMV infection is associated with a high maternalto-child transmission rate (40%); up to 15% of these infected neonates will be symptomatic at birth and develop permanent sequelae that usually involve the central nervous system. New interventions are now available to decrease the rate of primary maternal infection as well as to treat pregnant women with primary infection, thus decreasing the fetal and neonatal morbidity associated with this disease. Based on these data, strategies for maternal screening need to be reconsidered.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/cit611