Changes in CD34+ cell count in peripheral blood after whole blood donation

Abstract Aim We aimed to investigate the change in the number of stem cells and white cells in the early period following blood donation. Patients and Method 22 male (71%) and 9 female (29%), 31 volunteers in total were included in the study. 450 ml of whole blood were collected from each of the vol...

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Bibliographic Details
Published in:Transfusion and apheresis science 2013-10, Vol.49 (2), p.259-262
Main Authors: Pala, Cigdem, Mumcuoglu, Haluk, Kurnaz, Fatih, Sivgin, Serdar, Kaynar, Leylagul, Keklik, Muzaffer, Akyol, Gulsah, Koker, Yavuz, Eser, Bulent
Format: Article
Language:English
Subjects:
Adult
Antigens, CD34 - blood
Blood donation
Blood Donors
CD34
Female
Health technology assessment
Hematology, Oncology and Palliative Medicine
Humans
Leukocyte Count
Male
Peripheral stem cell
Stem Cells
Time Factors
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Summary:Abstract Aim We aimed to investigate the change in the number of stem cells and white cells in the early period following blood donation. Patients and Method 22 male (71%) and 9 female (29%), 31 volunteers in total were included in the study. 450 ml of whole blood were collected from each of the volunteers for the donation. Complete blood counts were performed on the volunteers before and at 6 and 24 h after the donation and CD34+ cell counts per ml of peripheral blood were measured by flow cytometry technique. Results There was a statistically significant increase in the number of CD34+ cells in the peripheral blood at 6 h following blood donation ( p < 0.001). At 24 h, however, there was a statistically significant decrease in the number of CD34+ cells, compared to 6 h ( p < 0.001). There was a statistically significant increase in the number of leukocytes in the peripheral blood at 6 h following blood donation ( p < 0.001). At 24 h, there was a decrease in the number of leukocytes, which was statistically significant compared to 6 h ( p < 0.001). When the difference in CD34+ cell and leukocytes counts before blood donation and at 24 h after blood donation were compared, the results were not statistically significant. Conclusion As the result of this study, a transient increase in the number of CD34+ cells in the peripheral blood after blood donation was demonstrated, with a decline in CD34+ cell counts back to levels prior to donation at 24 h.
ISSN:1473-0502
1878-1683
DOI:10.1016/j.transci.2013.04.038