The effect of automobile exhaust particulates on cell viability, plating efficiency and cell division of mammalian tissue culture cells

Extract of particulate matter (EPM) of gasoline engine exhaust induced only a slight loss of cell viability of mouse macrophages (line IC-21) in vitro, while a strong dose-dependent reduction of plating efficiency of human cell line A-549 and of Syrian hamster line 14-1b occurred. Cytological invest...

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Bibliographic Details
Published in:The Science of the total environment 1987, Vol.61, p.107-115
Main Authors: Seemayer, N.H., Hadnagy, W., Tomingas, R.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Division - drug effects
Cell Line
Cell Survival - drug effects
Cells, Cultured
Cricetinae
Environmental pollutants toxicology
Humans
Medical sciences
Mesocricetus
Mice
Toxicology
Vehicle Emissions - toxicity
Water
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Summary:Extract of particulate matter (EPM) of gasoline engine exhaust induced only a slight loss of cell viability of mouse macrophages (line IC-21) in vitro, while a strong dose-dependent reduction of plating efficiency of human cell line A-549 and of Syrian hamster line 14-1b occurred. Cytological investigations of exposed macrophages of line IC-21 revealed an increase in the mitotic index from 1.5% of control values up to 14.6% at the highest tested concentration of EPM. Mitotic arrest is based almost exclusively on C-type mitoses occurring dose-dependently in the presence of EPM. Results indicate disturbances of the spindle apparatus in the presence of EPM.
ISSN:0048-9697
1879-1026
DOI:10.1016/0048-9697(87)90360-3