Long-term follow-up of early mycosis fungoides patients treated with narrowband ultraviolet B phototherapy

Background: Narrowband ultraviolet B (UVB) provides complete response (CR) in 54-91% of early mycosis fungoides (MF) patients. Data concerning relapse rate and relapse-free interval after discontinuation of therapy need clarification. The purpose of this study was to evaluate the relapse rate and th...

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Published in:The Journal of dermatological treatment 2014-06, Vol.25 (3), p.268-273
Main Authors: Elcin, Gonca, Duman, Nilay, Karahan, Sevilay, Ersoy-Evans, Sibel, Erkin, Gul, Karaduman, Aysen, Hapa, Asli, Atakan, Nilgün, Akan, Tulin, ahin, Sedef
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Dermatology
Female
Follow-Up Studies
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
mycosis fungoides
Mycosis Fungoides - therapy
Pharmacology. Drug treatments
phototherapy
Retrospective Studies
Skin, nail, hair, dermoskeleton
ultraviolet B
Ultraviolet Therapy - methods
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Summary:Background: Narrowband ultraviolet B (UVB) provides complete response (CR) in 54-91% of early mycosis fungoides (MF) patients. Data concerning relapse rate and relapse-free interval after discontinuation of therapy need clarification. The purpose of this study was to evaluate the relapse rate and the relapse-free intervals of early MF patients after achieving complete response with narrowband UVB phototherapy. Methods: Retrospective evaluation of data, which belong to early MF patients treated with narrowband UVB phototherapy between May 2000 and July 2010, and followed-up until May 2012 in a single institution, for the occurrence of relapse and the time to relapse. Results: Of 31 patients, who were followed-up for a mean of 56.5 ± 30.2 months (median 55 months, range 20-120 months), relapse was observed in 11 (35.5%) patients, within a mean of 28.8 ± 18.2 months (median 33 months, range 4-59 months), whereas 20 (64.5%) patients stayed relapse-free for a mean of 54.2 ± 28.8 months (median 55.5 months, range 20-119 months). Patients received maintenance phototherapy with a median duration of 12 months (range 1-30 months) after achieving complete response. Conclusion: Results indicate that narrowband UVB phototherapy may induce low relapse rates and long relapse-free intervals for early MF.
ISSN:0954-6634
1471-1753
DOI:10.3109/09546634.2012.735638