Dibromoacetic Acid, a Commonly Occurring Water Disinfection By-Product, Does not Affect Follicular Populations in Neonatal Rats

To investigate the timing of dibromoacetic acid (DBA) toxicity, follicular populations in female neonatal rats exposed to DBA were examined. The objective was to investigate whether the mechanism of DBA toxicity involved disruption of primordial germ cell migration and/or follicular formation. Pregn...

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Bibliographic Details
Published in:Journal of toxicology and environmental health. Part A 2006-01, Vol.69 (5), p.491-491
Main Authors: teRiele, Jaclyn A, Bodensteiner, Karin J
Format: Article
Language:English
Online Access:Get full text
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Summary:To investigate the timing of dibromoacetic acid (DBA) toxicity, follicular populations in female neonatal rats exposed to DBA were examined. The objective was to investigate whether the mechanism of DBA toxicity involved disruption of primordial germ cell migration and/or follicular formation. Pregnant and lactating female Sprague-Dawley rats were gavaged daily with 0, 1, 5, or 50 mg DBA/kg body weight beginning on gestation day 17 and continuing through postnatal day 7. Maternal weight, litter size, and gender ratio did not differ across treatment groups, and major organ weights did not differ from control. Follicular populations at all stages of development did not differ among treatment groups. These data suggested that rodents might not be useful model for DBA toxicity assessment.
ISSN:1528-7394