Identification of Human Immunodeficiency Virus Subtypes with Distinct Patterns of Sensitivity to Serum Neutralization

The human immunodeficiency virus (HIV) type 1 displays a high degree of genetic variation, especially in the glycoprotein (gp120) domain of the envelope gene. To determine whether this genomic heterogeneity leads to the expression of independent HIV subtypes, 12 sera from HIV type 1 antibody-positiv...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1988-04, Vol.85 (8), p.2815-2819
Main Authors: Cheng-Mayer, C., Homsy, J., Evans, L. A., Levy, J. A.
Format: Article
Language:English
Subjects:
AIDS
AIDS/HIV
Antibodies
Biological and medical sciences
Central nervous system
Fundamental and applied biological sciences. Psychology
HIV
HIV - classification
HIV - immunology
HIV 1
human immunodeficiency virus
Kinetics
Microbiology
Molecular Weight
Nerve tissue
Neutralization Tests
Reactivity
Retroviridae Proteins - analysis
Retroviridae Proteins - immunology
Serotyping
Systematics
Vaccination
Viral Envelope Proteins - immunology
Viral proteins
Virology
Viruses
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Summary:The human immunodeficiency virus (HIV) type 1 displays a high degree of genetic variation, especially in the glycoprotein (gp120) domain of the envelope gene. To determine whether this genomic heterogeneity leads to the expression of independent HIV subtypes, 12 sera from HIV type 1 antibody-positive individuals were tested for their ability to neutralize 20 HIV isolates of various origins. Four distinct HIV subtypes with different sensitivity to serum neutralization were identified. These results suggest that a finite number of HIV subtypes exist and that the combined use of selected HIV isolates representing several subtypes may be necessary for the development of an effective vaccine.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.85.8.2815