Antimicrobial efficacy of a novel silver hydrogel dressing compared to two common silver burn wound dressings: Acticoat™ and PolyMem Silver

Abstract A novel burn wound hydrogel dressing has been previously developed which is composed of 2-acrylamido-2-methylpropane sulfonic acid sodium salt with silver nanoparticles. This study compared the antimicrobial efficacy of this novel dressing to two commercially available silver dressings; Act...

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Bibliographic Details
Published in:Burns 2014-02, Vol.40 (1), p.89-96
Main Authors: Boonkaew, Benjawan, Kempf, Margit, Kimble, Roy, Supaphol, Pitt, Cuttle, Leila
Format: Article
Language:English
Subjects:
Acinetobacter baumannii - drug effects
Acrylamides - pharmacology
Alkanesulfonates - pharmacology
Anti-Infective Agents, Local - pharmacology
Antimicrobial
Bandages, Hydrocolloid
Broth culture
Burns - therapy
Candida albicans - drug effects
Critical Care
Disc diffusion
Dressing
Enterococcus - drug effects
Glycerol - pharmacology
Humans
Live/Dead
Metal Nanoparticles
Methicillin-Resistant Staphylococcus aureus - drug effects
Microbial Sensitivity Tests
Polyesters - pharmacology
Polyethylenes - pharmacology
Polyurethanes - pharmacology
Pseudomonas aeruginosa - drug effects
Silver
Silver - pharmacology
Staphylococcus aureus - drug effects
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Summary:Abstract A novel burn wound hydrogel dressing has been previously developed which is composed of 2-acrylamido-2-methylpropane sulfonic acid sodium salt with silver nanoparticles. This study compared the antimicrobial efficacy of this novel dressing to two commercially available silver dressings; Acticoat™ and PolyMem Silver® . Three different antimicrobial tests were used: disc diffusion, broth culture, and the Live/Dead® Baclight™ bacterial viability assay. Burn wound pathogens ( P. aeruginosa , MSSA, A. baumannii and C. albicans ) and antibiotic resistant strains (MRSA and VRE) were tested. All three antimicrobial tests indicated that Acticoat™ was the most effective antimicrobial agent, with inhibition zone lengths of 13.9–18.4 mm. It reduced the microbial inocula below the limit of detection (102 CFU/ml) and reduced viability by 99% within 4 h. PolyMem Silver® had no zone of inhibition for most tested micro-organisms, and it also showed poor antimicrobial activity in the broth culture and Live/Dead® Baclight™ assays. Alarmingly, it appeared to promote the growth of VRE. The silver hydrogel reduced most of the tested microbial inocula below the detection limit and decreased bacterial viability by 94–99% after 24 h exposure. These results support the possibility of using this novel silver hydrogel as a burn wound dressing in the future.
ISSN:0305-4179
1879-1409
DOI:10.1016/j.burns.2013.05.011