Neurocognitive Dysfunction and Regional Cerebral Blood Flow in Medically Naïve Patients With Obsessive-Compulsive Disorder

Previous research characterizes obsessive compulsive disorder (OCD) as a complex neurobehavioral disorder that may have multiple etiologies ( den Braber et al., 2008 ). This study analyzed neurocognitive function and change in regional cerebral blood flow (rCBF) to characterize OCD. Neurocognitive f...

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Bibliographic Details
Published in:Developmental neuropsychology 2014-01, Vol.39 (1), p.37-50
Main Authors: Wen, Sheng-lin, Cheng, Min-feng, Cheng, Mu-hua, Yue, Ji-hui, Li, Jian-fang, Xie, Liang-jun
Format: Article
Language:English
Subjects:
Adult
Attention
Attention - physiology
Blood
Cerebral Cortex - blood supply
Cerebral Cortex - physiology
Cerebrovascular Circulation - physiology
Cognition & reasoning
Cognition Disorders - pathology
Cognition Disorders - physiopathology
Electroencephalography
Executive Function - physiology
Female
Humans
Magnetic Resonance Imaging
Male
Memory - physiology
Neurological disorders
Neuropsychology
Neuroses
Obsessive-Compulsive Disorder - diagnostic imaging
Obsessive-Compulsive Disorder - physiopathology
Obsessive-Compulsive Disorder - psychology
Psychiatric Status Rating Scales
Radionuclide Imaging
Tomography, X-Ray Computed
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Summary:Previous research characterizes obsessive compulsive disorder (OCD) as a complex neurobehavioral disorder that may have multiple etiologies ( den Braber et al., 2008 ). This study analyzed neurocognitive function and change in regional cerebral blood flow (rCBF) to characterize OCD. Neurocognitive function and rCBF were examined in medically naïve patients with OCD and contrasted with controls. Results of this study indicated that the neurocognitive functions impaired in OCD are memory, attention, and executive function, which are primarily associated with the frontal and occipital lobes. Dysfunction in the basal ganglia and occipital lobes were associated with OCD and may be an etiological factor in the disorder.
ISSN:8756-5641
1532-6942
DOI:10.1080/87565641.2013.839682