The questionable use of unequal allocation in confirmatory trials

Randomization is the standard means for addressing known and unknown confounders within the patient population in clinical trials. Although random assignment to treatment arms on a 1:1 basis has long been the norm, many 2-armed confirmatory trials now use unequal allocation schemes where the number...

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Bibliographic Details
Published in:Neurology 2014-01, Vol.82 (1), p.77-79
Main Authors: Hey, Spencer Phillips, Kimmelman, Jonathan
Format: Article
Language:English
Subjects:
Animals
Clinical Protocols - standards
Contemporary Issues
Humans
Random Allocation
Randomized Controlled Trials as Topic - methods
Randomized Controlled Trials as Topic - standards
Research Design - standards
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