Lean mass as a predictor of bone density and microarchitecture in adult obese individuals with metabolic syndrome

• Published in: Bone (New York, N.Y.) N.Y.), 2014-02, Vol.59, p.89-92
• Main Authors: Madeira, Eduardo, Mafort, Thiago Thomaz, Madeira, Miguel, Guedes, Erika Paniago, Moreira, Rodrigo Oliveira, de Mendonça, Laura Maria Carvalho, Lima, Inayá Correa Barbosa, de Pinho, Paulo Roberto Alves, Lopes, Agnaldo José, Farias, Maria Lucia Fleiuss
• Format: Article
• Language: English
• Subjects: Adipose Tissue - anatomy & histology; Adult; Biological and medical sciences; Body Composition; Bone and Bones - anatomy & histology; Bone and Bones - diagnostic imaging; Bone and Bones - pathology; Bone Density; Bone microarchitecture; Bone mineral density; Female; Fundamental and applied biological sciences. Psychology; High-resolution peripheral quantitative computed tomography; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Metabolic diseases; Metabolic syndrome; Metabolic Syndrome - complications; Metabolic Syndrome - diagnostic imaging; Metabolic Syndrome - physiopathology; Multivariate Analysis; Obesity; Obesity - complications; Obesity - diagnostic imaging; Obesity - physiopathology; Organ Size; Orthopedics; Osteoarticular system. Muscles; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Tomography, X-Ray Computed; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 8756-3282; 1873-2763
• DOI: 10.1016/j.bone.2013.11.004

Abstract The effects of obesity and metabolic syndrome (MS) on bone health are controversial. Furthermore, the relationship between body composition and bone quality has not yet been determined in this context. The aim of this study was to investigate the correlations between body composition and bone mineral density (BMD) and bone microstructure in obese individuals with MS. This cross-sectional study assessed 50 obese individuals with MS with respect to their body composition and BMD, both assessed using dual X-ray absorptiometry, and bone microarchitecture, assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) of the distal tibia and radius. Several HR-pQCT measurements exhibited statistically significant correlations with lean mass. Lean mass was positively correlated with parameters of better bone quality (r: 0.316–0.470) and negatively correlated with parameters of greater bone fragility (r: − 0.460 to − 0.310). Positive correlations were also observed between lean mass and BMD of the total femur and radius 33%. Fat mass was not significantly correlated with BMD or any HR-pQCT measurements. Our data suggest that lean mass might be a predictor of bone health in obese individuals with MS.