Perforation as a rare presentation of gastric gastrointestinal stromal tumours: a case report and review of the literature

Gastrointestinal stromal tumours (GISTs) are the most common connective tissue neoplasms of the gastrointestinal tract, the most common clinical presentation of which is with abdominal pain or gastrointestinal bleeding. We describe a case of a perforated gastric GIST as well as reviewing the relevan...

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Bibliographic Details
Published in:Annals of the Royal College of Surgeons of England 2014-01, Vol.96 (1), p.96E-5
Main Authors: Skipworth, J R A, Fanshawe, A E E, West, M J, Al-Bahrani, A
Format: Article
Language:English
Subjects:
Abdomen
Anastomosis, Roux-en-Y
Cardiovascular disease
Case reports
Chemotherapy
Family medical history
Female
Gastrectomy - methods
Gastrointestinal cancer
Gastrointestinal Stromal Tumors - complications
Gastrointestinal Stromal Tumors - surgery
Humans
Hypertension
Intestinal Perforation - etiology
Intestinal Perforation - surgery
Middle Aged
Mutation
Pain
Small intestine
Stomach Neoplasms - complications
Stomach Neoplasms - surgery
Surgery
Tumors
Ultrasonic imaging
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Summary:Gastrointestinal stromal tumours (GISTs) are the most common connective tissue neoplasms of the gastrointestinal tract, the most common clinical presentation of which is with abdominal pain or gastrointestinal bleeding. We describe a case of a perforated gastric GIST as well as reviewing the relevant published literature. A 51-year-old woman presented to the acute assessment unit with a 1-day history of severe epigastric pain on a background of longstanding reflux symptoms. Radiological investigation demonstrated a perforated mass in the gastric antrum and the patient subsequently underwent an emergency distal gastrectomy. She recovered well postoperatively and was discharged home. Her condition remains stable six months following surgery. Histological analysis revealed the perforated lesion to be a GIST. A PubMed search suggests that this is the first English report to describe a perforated gastric GIST. Six further published reports (written in English or with an English abstract) describing the presentation of small bowel GISTs with perforation are reviewed. We present the first English report of a perforated gastric GIST. More common presentations include abdominal pain and gastrointestinal bleeding. Although rare, GISTs should be considered in the differential diagnoses of perforated gastrointestinal masses.
ISSN:0035-8843
1478-7083
DOI:10.1308/003588414X13824511650010