Clinical usefulness of non-protein respiratory quotient measurement in non-alcoholic fatty liver disease

Aim Little is known about the effects of non‐alcoholic fatty liver disease (NAFLD) on energy metabolism, although this disease is associated with metabolic syndrome. We measured non‐protein respiratory quotient (npRQ) using indirect calorimetry, which reflects glucose oxidation, and compared this va...

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Published in:Hepatology research 2013-12, Vol.43 (12), p.1284-1294
Main Authors: Korenaga, Keiko, Korenaga, Masaaki, Teramoto, Fusako, Suzuki, Toshiko, Nishina, Sohji, Sasaki, Kyo, Nakashima, Yoshihiro, Tomiyama, Yasuyuki, Yoshioka, Naoko, Hara, Yuichi, Moriya, Takuya, Hino, Keisuke
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glucose intolerance
NAFLD
npRQ
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cited_by cdi_FETCH-LOGICAL-c4575-2922ba4e61908ac598836f9591e65ac678d2072bce937acf3afd236125c944003
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container_issue 12
container_start_page 1284
container_title Hepatology research
container_volume 43
creator Korenaga, Keiko
Korenaga, Masaaki
Teramoto, Fusako
Suzuki, Toshiko
Nishina, Sohji
Sasaki, Kyo
Nakashima, Yoshihiro
Tomiyama, Yasuyuki
Yoshioka, Naoko
Hara, Yuichi
Moriya, Takuya
Hino, Keisuke
description Aim Little is known about the effects of non‐alcoholic fatty liver disease (NAFLD) on energy metabolism, although this disease is associated with metabolic syndrome. We measured non‐protein respiratory quotient (npRQ) using indirect calorimetry, which reflects glucose oxidation, and compared this value with histological disease severity in NAFLD patients. Methods Subjects were 32 patients who were diagnosed with NAFLD histopathologically. Subjects underwent body composition analysis and indirect calorimetry, and npRQ was calculated. An oral glucose tolerance test was performed, and plasma glucose area under the curve (AUC glucose) was calculated. Results There were no differences in body mass index, body fat percentage or visceral fat area among fibrosis stage groups. As fibrosis progressed, npRQ significantly decreased (stage 0, 0.895 ± 0.068; stage 1, 0.869 ± 0.067; stage 2, 0.808 ± 0.046; stage 3, 0.798 ± 0.026; P 
doi_str_mv 10.1111/hepr.12095
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We measured non‐protein respiratory quotient (npRQ) using indirect calorimetry, which reflects glucose oxidation, and compared this value with histological disease severity in NAFLD patients. Methods Subjects were 32 patients who were diagnosed with NAFLD histopathologically. Subjects underwent body composition analysis and indirect calorimetry, and npRQ was calculated. An oral glucose tolerance test was performed, and plasma glucose area under the curve (AUC glucose) was calculated. Results There were no differences in body mass index, body fat percentage or visceral fat area among fibrosis stage groups. As fibrosis progressed, npRQ significantly decreased (stage 0, 0.895 ± 0.068; stage 1, 0.869 ± 0.067; stage 2, 0.808 ± 0.046; stage 3, 0.798 ± 0.026; P &lt; 0.005). Glucose intolerance worsened and insulin resistance increased with fibrosis stage. npRQ was negatively correlated with AUC glucose (R = −0.6308, P &lt; 0.001), Homeostasis Model of Assessment – Insulin Resistance (R = −0.5045, P &lt; 0.005), fasting glucose (R = −0.4585, P &lt; 0.01) and insulin levels (R = −0.4431, P &lt; 0.05), suggesting that decreased npRQ may reflect impaired glucose tolerance due to insulin resistance, which was associated with fibrosis progression. Estimation of fibrosis stage using npRQ was as accurate as several previously established scoring systems using receiver–operator curve analysis. Conclusion npRQ was significantly decreased in patients with advanced NAFLD. Our data suggest that measurement of npRQ is useful for the estimation of disease severity in NAFLD patients.</description><identifier>ISSN: 1386-6346</identifier><identifier>EISSN: 1872-034X</identifier><identifier>DOI: 10.1111/hepr.12095</identifier><identifier>PMID: 23510120</identifier><language>eng</language><publisher>Netherlands: Blackwell Publishing Ltd</publisher><subject>glucose intolerance ; NAFLD ; npRQ</subject><ispartof>Hepatology research, 2013-12, Vol.43 (12), p.1284-1294</ispartof><rights>2013 The Japan Society of Hepatology</rights><rights>2013 The Japan Society of Hepatology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4575-2922ba4e61908ac598836f9591e65ac678d2072bce937acf3afd236125c944003</citedby><cites>FETCH-LOGICAL-c4575-2922ba4e61908ac598836f9591e65ac678d2072bce937acf3afd236125c944003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23510120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Korenaga, Keiko</creatorcontrib><creatorcontrib>Korenaga, Masaaki</creatorcontrib><creatorcontrib>Teramoto, Fusako</creatorcontrib><creatorcontrib>Suzuki, Toshiko</creatorcontrib><creatorcontrib>Nishina, Sohji</creatorcontrib><creatorcontrib>Sasaki, Kyo</creatorcontrib><creatorcontrib>Nakashima, Yoshihiro</creatorcontrib><creatorcontrib>Tomiyama, Yasuyuki</creatorcontrib><creatorcontrib>Yoshioka, Naoko</creatorcontrib><creatorcontrib>Hara, Yuichi</creatorcontrib><creatorcontrib>Moriya, Takuya</creatorcontrib><creatorcontrib>Hino, Keisuke</creatorcontrib><title>Clinical usefulness of non-protein respiratory quotient measurement in non-alcoholic fatty liver disease</title><title>Hepatology research</title><addtitle>Hepatol Res</addtitle><description>Aim Little is known about the effects of non‐alcoholic fatty liver disease (NAFLD) on energy metabolism, although this disease is associated with metabolic syndrome. We measured non‐protein respiratory quotient (npRQ) using indirect calorimetry, which reflects glucose oxidation, and compared this value with histological disease severity in NAFLD patients. Methods Subjects were 32 patients who were diagnosed with NAFLD histopathologically. Subjects underwent body composition analysis and indirect calorimetry, and npRQ was calculated. An oral glucose tolerance test was performed, and plasma glucose area under the curve (AUC glucose) was calculated. Results There were no differences in body mass index, body fat percentage or visceral fat area among fibrosis stage groups. As fibrosis progressed, npRQ significantly decreased (stage 0, 0.895 ± 0.068; stage 1, 0.869 ± 0.067; stage 2, 0.808 ± 0.046; stage 3, 0.798 ± 0.026; P &lt; 0.005). Glucose intolerance worsened and insulin resistance increased with fibrosis stage. npRQ was negatively correlated with AUC glucose (R = −0.6308, P &lt; 0.001), Homeostasis Model of Assessment – Insulin Resistance (R = −0.5045, P &lt; 0.005), fasting glucose (R = −0.4585, P &lt; 0.01) and insulin levels (R = −0.4431, P &lt; 0.05), suggesting that decreased npRQ may reflect impaired glucose tolerance due to insulin resistance, which was associated with fibrosis progression. Estimation of fibrosis stage using npRQ was as accurate as several previously established scoring systems using receiver–operator curve analysis. Conclusion npRQ was significantly decreased in patients with advanced NAFLD. 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We measured non‐protein respiratory quotient (npRQ) using indirect calorimetry, which reflects glucose oxidation, and compared this value with histological disease severity in NAFLD patients. Methods Subjects were 32 patients who were diagnosed with NAFLD histopathologically. Subjects underwent body composition analysis and indirect calorimetry, and npRQ was calculated. An oral glucose tolerance test was performed, and plasma glucose area under the curve (AUC glucose) was calculated. Results There were no differences in body mass index, body fat percentage or visceral fat area among fibrosis stage groups. As fibrosis progressed, npRQ significantly decreased (stage 0, 0.895 ± 0.068; stage 1, 0.869 ± 0.067; stage 2, 0.808 ± 0.046; stage 3, 0.798 ± 0.026; P &lt; 0.005). Glucose intolerance worsened and insulin resistance increased with fibrosis stage. npRQ was negatively correlated with AUC glucose (R = −0.6308, P &lt; 0.001), Homeostasis Model of Assessment – Insulin Resistance (R = −0.5045, P &lt; 0.005), fasting glucose (R = −0.4585, P &lt; 0.01) and insulin levels (R = −0.4431, P &lt; 0.05), suggesting that decreased npRQ may reflect impaired glucose tolerance due to insulin resistance, which was associated with fibrosis progression. Estimation of fibrosis stage using npRQ was as accurate as several previously established scoring systems using receiver–operator curve analysis. Conclusion npRQ was significantly decreased in patients with advanced NAFLD. Our data suggest that measurement of npRQ is useful for the estimation of disease severity in NAFLD patients.</abstract><cop>Netherlands</cop><pub>Blackwell Publishing Ltd</pub><pmid>23510120</pmid><doi>10.1111/hepr.12095</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record>
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subjects glucose intolerance
NAFLD
npRQ
title Clinical usefulness of non-protein respiratory quotient measurement in non-alcoholic fatty liver disease
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