Less small airway dysfunction in asymptomatic bronchial hyperresponsiveness than in asthma

Background Bronchial hyperresponsiveness (BHR) can be present in subjects without any respiratory symptoms. Little is known about the role of the small airways in asymptomatic subjects with BHR. Methods We investigated small airway function assessed by spirometry and impulse oscillometry, as well as...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2013-11, Vol.68 (11), p.1419-1426
Main Authors: Boudewijn, I. M., Telenga, E. D., Wiel, E., Molen, T., Schiphof, L., ten Hacken, N. H. T., Postma, D. S., Berge, M.
Format: Article
Language:English
Subjects:
Adult
Airway management
Allergies
Asthma
Asthma - epidemiology
Asthma - immunology
Asthma - physiopathology
asymptomatic bronchial hyperresponsiveness
Asymptomatic Diseases - epidemiology
Body Mass Index
Bronchial Hyperreactivity - epidemiology
Bronchial Hyperreactivity - immunology
Bronchial Hyperreactivity - physiopathology
Cross-Sectional Studies
Female
Humans
Male
Methacholine Chloride - administration & dosage
Middle Aged
Pulmonary Disease, Chronic Obstructive - epidemiology
Randomized Controlled Trials as Topic - trends
Respiratory system
small airways
Young Adult
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Summary:Background Bronchial hyperresponsiveness (BHR) can be present in subjects without any respiratory symptoms. Little is known about the role of the small airways in asymptomatic subjects with BHR. Methods We investigated small airway function assessed by spirometry and impulse oscillometry, as well as Borg dyspnea scores at baseline and during a methacholine provocation test in 15 subjects with asymptomatic BHR, 15 asthma patients, and 15 healthy controls. Results At baseline, small airway function (R5–R20 and X5) was comparable between subjects with asymptomatic BHR and healthy controls, whereas asthma patients showed small airway dysfunction as reflected by higher R5–R20 and lower X5 values. During methacholine provocation, small airway dysfunction was more severe in asthma patients than in subjects with asymptomatic BHR. Interestingly, a higher increase in small airway dysfunction during methacholine provocation was associated with a higher increase in Borg dyspnea scores in subjects with asymptomatic BHR, but not in asthma patients. Conclusion Subjects with asymptomatic BHR may experience fewer symptoms in daily life because they have less small airway dysfunction.
ISSN:0105-4538
1398-9995
DOI:10.1111/all.12242