Obesity affects short-term folate pharmacokinetics in women of childbearing age

Maternal folate status and body mass index (BMI) are independent risk factors for neural tube defects (NTD). Population-based studies have identified an inverse association between serum folate and BMI, after adjusting for intake. The objective of this intervention study was to compare the relations...

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Bibliographic Details
Published in:International Journal of Obesity 2013-12, Vol.37 (12), p.1608-1610
Main Authors: da Silva, V R, Hausman, D B, Kauwell, G P A, Sokolow, A, Tackett, R L, Rathbun, S L, Bailey, L B
Format: Article
Language:English
Subjects:
631/92/436/1729
692/699/1702/393
692/699/375/361
Abnormalities
Absorption
Acids
Adolescent
Adult
Age
Biological and medical sciences
Birth defects
Blood
Body Mass Index
Complications and side effects
Dietary Supplements
Diseases of the osteoarticular system
Diseases of the spine
Embryos
Epidemiology
Erythrocytes
Female
Folic acid
Folic Acid - administration & dosage
Folic Acid - blood
Folic Acid - pharmacokinetics
Health aspects
Health care
Health Promotion and Disease Prevention
Humans
Internal Medicine
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Mothers
Neural tube
Neural Tube Defects - etiology
Neural Tube Defects - prevention & control
Nutrition
Obesity
Obesity - blood
Obesity - complications
Overweight
Pharmacokinetics
Physiological aspects
Population studies
Pregnancy
Prenatal Care - methods
Public Health
Risk Factors
Risk reduction
short-communication
Variance analysis
Vitamin B
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Summary:Maternal folate status and body mass index (BMI) are independent risk factors for neural tube defects (NTD). Population-based studies have identified an inverse association between serum folate and BMI, after adjusting for intake. The objective of this intervention study was to compare the relationship between BMI and the short-term pharmacokinetic response to an oral dose of folic acid. Healthy obese (BMI ⩾30.0 kg m −2 ; n =16) and normal-weight (BMI 18.5–24.9 kg m −2 ; n =16) women of childbearing age (18–35 years) were administered a single oral dose of folic acid (400 μg). Blood samples were collected over a 10-h period to evaluate the serum folate response. Fasting baseline serum folate was lower in the obese group ( P =0.005); in contrast, red blood cell folate was higher ( P =0.05). Area-under-the-curve for the absorption phase (0–3 h) and peak serum folate concentrations were lower in obese versus normal-weight women ( P
ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2013.41