Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

The efficacy of kinase inhibitors in treating cancer is limited by drug resistance; here it is shown that most human tumour cells can develop drug resistance through being exposed to one or more receptor tyrosine kinase ligands. BRAF/MET inhibitor to treat melanoma Targeted anticancer therapies are...

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Bibliographic Details
Published in:	Nature (London) 2012-07, Vol.487 (7408), p.505-509
Main Authors:	Wilson, Timothy R., Fridlyand, Jane, Yan, Yibing, Penuel, Elicia, Burton, Luciana, Chan, Emily, Peng, Jing, Lin, Eva, Wang, Yulei, Sosman, Jeff, Ribas, Antoni, Li, Jiang, Moffat, John, Sutherlin, Daniel P., Koeppen, Hartmut, Merchant, Mark, Neve, Richard, Settleman, Jeff
Format:	Article
Language:	English
Subjects:	631/67/1059/2326 631/80/86 631/92/609 Antimitotic agents Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Biomarkers Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Survival - drug effects Chemotherapy Drug resistance Drug Resistance, Neoplasm - drug effects Epidermal growth factor Female General aspects Growth factors Health aspects Hepatocyte Growth Factor - metabolism Hepatocyte Growth Factor - pharmacology Humanities and Social Sciences Humans Indoles - pharmacology Inhibitors Insulin-like growth factors Kinases letter Ligands Medical sciences Melanoma Melanoma - drug therapy Melanoma - enzymology Melanoma - genetics Melanoma - pathology Mitogen-Activated Protein Kinases - metabolism multidisciplinary Pharmacology. Drug treatments Phosphatidylinositol 3-Kinases - metabolism Phosphotransferases Physiological aspects Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins B-raf - antagonists & inhibitors Proto-Oncogene Proteins B-raf - genetics Quinazolines - pharmacology Receptor Protein-Tyrosine Kinases - metabolism Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Rodents Science Science (multidisciplinary) Signal Transduction - drug effects Substance abuse treatment Sulfonamides - pharmacology Tumors
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