Expression of an anti‐RNA autoantibody in a mouse model of SLE increases neutrophil and monocyte numbers as well as IFN‐I expression

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the presence of antinucleic acid autoantibodies, high levels of circulating type I interferon (IFN‐I), and an IFN‐I‐dependent elevated expression of activating FcγR. Increases in neutrophils and monocytes are often observed...

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Bibliographic Details
Published in:European journal of immunology 2014-01, Vol.44 (1), p.215-226
Main Authors: Han, Jin‐Hwan, Umiker, Benjamin R., Kazimirova, Anastasia A., Fray, Michael, Korgaonkar, Parimal, Selsing, Erik, Imanishi‐Kari, Thereza
Format: Article
Language:English
Subjects:
Animals
Autoantibodies - metabolism
Autoantibody
Autocrine Communication
Autoimmune diseases
B-Lymphocytes - immunology
Cell Growth Processes - genetics
Cells, Cultured
Disease Models, Animal
Fcγ receptors
Gene Expression Profiling
Gene Expression Regulation - genetics
Genes, Immunoglobulin - genetics
Humans
Immune system
Immunoglobulin G - metabolism
Interferon Type I - genetics
Interferon Type I - metabolism
Lupus Erythematosus, Systemic - immunology
Membrane Glycoproteins - metabolism
Mice
Mice, Inbred C57BL
Mice, Transgenic
Monocytes - immunology
Myeloid cells
Neutrophils - immunology
Receptors, IgG - metabolism
RNA - immunology
Systemic lupus erythematosus
Toll-Like Receptor 7 - metabolism
Type I interferon (IFN‐I)
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