Anti-asthmatic Effects of Baicalin in a Mouse Model of Allergic Asthma

The aim of the study was to investigate the anti‐asthmatic effects of baicalin (BA) and the possible mechanisms. Asthma model was established by ovalbumin (OVA) intraperitoneal injection. A total of 60 mice were randomly assigned to six experimental groups: control, model, dexamethasone (2 mg/kg), a...

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Bibliographic Details
Published in:Phytotherapy research 2014-02, Vol.28 (2), p.231-237
Main Authors: Ma, Chunhua, Ma, Zhangqiang, Fu, Qiang, Ma, Shiping
Format: Article
Language:English
Subjects:
Airway Resistance - drug effects
Animals
Anti-Asthmatic Agents - pharmacology
anti-asthmatic effects
Asthma - chemically induced
Asthma - drug therapy
Asthma - pathology
baicalin
Bronchoalveolar Lavage Fluid
Disease Models, Animal
Eosinophilia - drug therapy
Eosinophils - drug effects
Female
Flavonoids - pharmacology
Immunoglobulin E - immunology
Interferon-gamma - immunology
Interleukin-17 - immunology
Interleukin-4 - immunology
Lung - drug effects
Lung - pathology
Lung Compliance - drug effects
Mice
Mice, Inbred BALB C
Ovalbumin
Th1/Th2
Th17
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Summary:The aim of the study was to investigate the anti‐asthmatic effects of baicalin (BA) and the possible mechanisms. Asthma model was established by ovalbumin (OVA) intraperitoneal injection. A total of 60 mice were randomly assigned to six experimental groups: control, model, dexamethasone (2 mg/kg), and BA (10 mg/kg, 20 mg/kg, 40 mg/kg). Airway resistance (RI) and lung compliance (Cdyn) were measured, histological studies were evaluated by the hematoxylin and eosin staining, Th1/Th2, OVA‐specific serum, and BALF IgE levels and Th17 cytokines were evaluated by enzyme‐linked immunosorbent assay, and Th17 cells was evaluated by flow cytometry (FCM). Our study demonstrated that BA inhibited OVA‐induced increases in RI and eosinophil count; interleukin (IL)‐4, IL‐17A levels, and Cdyn were recovered and increased IFN‐γ level in bronchoalveolar lavage fluid. Histological studies demonstrated that BA substantially inhibited OVA‐induced eosinophilia in lung tissue and airway tissue. FCM studies demonstrated that BA substantially inhibited Th17 cells. These findings suggest that BA may effectively ameliorate the progression of asthma and could be used as a therapy for patients with allergic asthma. Copyright © 2013 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.4983