In vivo monitoring of implant osseointegration in a rabbit model using acoustic sound analysis

ABSTRACT Implant osseointegration can currently only be assessed reliably post mortem. A novel method that relies on the principle of acoustic sound analysis was developed to enable examination of the longitudinal progress of osseointegration. The method is based on a magnetic sphere inside a hollow...

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Bibliographic Details
Published in:Journal of orthopaedic research 2014-04, Vol.32 (4), p.606-612
Main Authors: Ruther, Cathérine, Gabler, Carolin, Ewald, Hartmut, Ellenrieder, Martin, Haenle, Maximilian, Lindner, Tobias, Mittelmeier, Wolfram, Bader, Rainer, Kluess, Daniel
Format: Article
Language:English
Subjects:
acoustic testing
Acoustics
animal experiment
Animals
Female
implant coating
Models, Animal
Osseointegration
Prostheses and Implants
Rabbits
Titanium
vibration analysis
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Summary:ABSTRACT Implant osseointegration can currently only be assessed reliably post mortem. A novel method that relies on the principle of acoustic sound analysis was developed to enable examination of the longitudinal progress of osseointegration. The method is based on a magnetic sphere inside a hollow cylinder of the implant. By excitation using an external magnetic field, collision of the sphere inside the implant produces a sound signal. Custom‐made titanium implants equipped thusly were inserted in each lateral femoral epicondyle of 20 New Zealand White Rabbits. Two groups were investigated: Uncoated, machined surface versus antiadhesive surface; and calcium phosphate‐coated surface versus antiadhesive surface. The sound analysis was performed postoperatively and weekly. After 4 weeks, the animals were euthanized, and the axial pull‐out strengths of the implants were determined. A significant increase in the central frequency was observed for the loose implants (mean pull‐out strength 21.1 ± 16.9 N), up to 6.4 kHz over 4 weeks. In comparison, the central frequency of the osseointegrated implants (105.2 ± 25.3 N) dropped to its initial value. The presented method shows potential for monitoring the osseointegration of different implant surfaces and could considerably reduce the number of animals needed for experiments. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:606–612, 2014.
ISSN:0736-0266
1554-527X
DOI:10.1002/jor.22574