Left ventricular oxidant and antioxidant markers induced by lifestyle modification in rats exposed to lead acetate

• Published in: European journal of sport science 2012-11, Vol.12 (6), p.485-490
• Main Authors: Dabidi Roshan, Valiollah, Ranjbar, Shima, Hosseinzadeh, Mahdi, Myers, Jonathan
• Format: Article
• Language: English
• Subjects: Activities; exercise training; heart; Oxidative stress markers; pollutant; turmeric
• ISSN: 1746-1391; 1536-7290
• DOI: 10.1080/17461391.2011.573579

Responses of the left ventricle oxidant/antioxidant markers such as glutathione peroxidase (GPx), superoxide dismutase (SOD), malondialdehyde (MDA) and protein carbonyls (PCs) induced by lifestyle modification, including turmeric supplementation and exercise training, were investigated in rats during chronic exposure to lead acetate. Forty male rats were randomly divided into five groups: (1) lead acetate; (2) turmeric; (3) endurance training; (4) training + turmeric; and (5) sham-operated groups. Enzyme activities were determined in rat hearts after receiving 20 mg·kg −1 of lead acetate (groups 1 to 4) and 30 mg·kg −1 turmeric (groups 2 and 4) for 8 weeks, three times a week. In addition, the rats in groups 3 and 4 performed treadmill running at a speed of 15 to 22 m·min −1 for 25 to 64 min, five times a week for 8 weeks. One way ANOVA analyses indicated that administration of lead evoked a significant increase in MDA and PC and significant decreases in GPx and SOD activity in the left ventricular homogenates. However, endurance training and\or turmeric supplementation resulted in a significant decrease in MDA and PC levels and significantly increased levels of GPx and SOD. These results suggest that lifestyle modification may have a cardioprotective effect by ameliorating lead-induced cardiotoxicity.