Repetitive transcranial magnetic stimulation reduces cigarette consumption in schizophrenia patients

• Published in: Progress in neuro-psychopharmacology & biological psychiatry 2014-03, Vol.49, p.30-35
• Main Authors: Prikryl, Radovan, Ustohal, Libor, Kucerova, Hana Prikrylova, Kasparek, Tomas, Jarkovsky, Jiri, Hublova, Veronika, Vrzalova, Michaela, Ceskova, Eva
• Format: Article
• Language: English
• Subjects: Addictive behaviors; Adolescent; Adult; Adult and adolescent clinical studies; Biological and medical sciences; Cigarettes; Consumption; Dorsolateral prefrontal cortex; Double-Blind Method; Humans; Male; Medical sciences; Middle Aged; Neuropharmacology; Pharmacology. Drug treatments; Prefrontal Cortex - physiology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenic Psychology; Smoking; Smoking - psychology; Smoking - therapy; Smoking Cessation - methods; Smoking Prevention; Stimulation; Symptom Assessment; Tobacco smoking; Tobacco, tobacco smoking; Toxicology; Transcranial Magnetic Stimulation; Young Adult
• ISSN: 0278-5846; 1878-4216
• DOI: 10.1016/j.pnpbp.2013.10.019

High-frequency repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC) seemed to decrease tobacco consumption and craving in nicotine-dependent people without psychiatric disorder or otherwise healthy people. Even if the prevalence of cigarette smoking in schizophrenia patients is high and estimated to be between 45% and 88%, this technique has not been systematically studied in this indication in schizophrenia yet. The aim of this study was to test the ability of high-frequency (10Hz) rTMS over the left DLPFC to decrease cigarette consumption in schizophrenia patients. The study included 35 male schizophrenia patients on stable antipsychotic medication. The patients were divided into two groups: the first (18 patients) were actively stimulated and the second (17 patients) underwent sham (placebo) stimulation. The sham rTMS was administered using a purpose-built sham coil that was identical in appearance to the real coil and made the same noise but did not deliver a substantial stimulus. The rTMS was administered at the stimulation parameters: location (left dorsolateral prefrontal cortex: DLPFC), intensity of magnetic stimulation in % of motor threshold (110%), stimulation frequency (10Hz), number of trains (20), single train duration (10s), inter-train interval (30s), and total number of stimulation sessions (21). In each stimulation session, 2000TMSpulses were given, with a total of 42,000pulses per treatment course. Patients noted the number of cigarettes smoked in the 7days before treatment, during the whole stimulation treatment (21days), and again for a 7-day period after treatment. Cigarette consumption was statistically significantly lower in the actively stimulated patients than in the sham rTMS group as early as the first week of stimulation. No statistically relevant correlations were found in the changes of ongoing negative or depressive schizophrenia symptoms and the number of cigarettes smoked. High-frequency rTMS over the left DLPFC has the ability to decrease the number of cigarettes smoked in schizophrenia patients. •The prevalence of cigarette smoking in schizophrenia patients is high.•Schizophrenia patients have even fewer treatment options for quitting smoking.•Neurostimulation represents an innovative treatment option of nicotine addiction.•Repetitive TMS decreases the number of cigarettes smoked in schizophrenia patients.