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Inactivation of human norovirus using chemical sanitizers
The porcine gastric mucin binding magnetic bead (PGM-MB) assay was used to evaluate the ability of chlorine, chlorine dioxide, peroxyacetic acid, hydrogen peroxide, and trisodium phosphate to inactivate human norovirus within 10% stool filtrate. One-minute free chlorine treatments at concentrations...
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| Published in: | International journal of food microbiology 2014-02, Vol.171, p.94-99 |
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| cites | cdi_FETCH-LOGICAL-c506t-2efa6ceb7ba3ea61cbb4078d9a08e7f8d373e4f988c0f6eaa411aa25578a82fc3 |
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| container_title | International journal of food microbiology |
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| creator | Kingsley, David H. Vincent, Emily M. Meade, Gloria K. Watson, Clytrice L. Fan, Xuetong |
| description | The porcine gastric mucin binding magnetic bead (PGM-MB) assay was used to evaluate the ability of chlorine, chlorine dioxide, peroxyacetic acid, hydrogen peroxide, and trisodium phosphate to inactivate human norovirus within 10% stool filtrate. One-minute free chlorine treatments at concentrations of 33 and 189ppm reduced virus binding in the PGM-MB assay by 1.48 and 4.14 log10, respectively, suggesting that chlorine is an efficient sanitizer for inactivation of human norovirus (HuNoV). Five minute treatments with 5% trisodium phosphate (pH~12) reduced HuNoV binding by 1.6 log10, suggesting that TSP, or some other high pH buffer, could be used to treat food and food contact surfaces to reduce HuNoV. One minute treatments with 350ppm chlorine dioxide dissolved in water did not reduce PGM-MB binding, suggesting that the sanitizer may not be suitable for HuNoV inactivation in liquid form. However a 60-min treatment with 350ppm chlorine dioxide did reduce human norovirus by 2.8 log10, indicating that chlorine dioxide had some, albeit limited, activity against HuNoV. Results also suggest that peroxyacetic acid has limited effectiveness against human norovirus, since 1-min treatments with up to 195ppm reduced human norovirus binding by |
| doi_str_mv | 10.1016/j.ijfoodmicro.2013.11.018 |
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•Human noroviruses (HuNoVs) interact with porcine gastric mucins (PGMs).•Inactivated HuNoVs do not interact with PGMs due to capsid damage.•PGM binding has been used to evaluate norovirus inactivation by chemical sanitizers.•HuNoV appears to be highly resistant to many common sanitizers.</description><identifier>ISSN: 0168-1605</identifier><identifier>EISSN: 1879-3460</identifier><identifier>DOI: 10.1016/j.ijfoodmicro.2013.11.018</identifier><identifier>PMID: 24334094</identifier><identifier>CODEN: IJFMDD</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Biological and medical sciences ; Caliciviridae Infections - prevention & control ; Chlorine ; Chlorine - pharmacology ; Chlorine Compounds - pharmacology ; Chlorine dioxide ; Disinfectants - pharmacology ; Food industries ; Food microbiology ; Fundamental and applied biological sciences. Psychology ; Human norovirus ; Humans ; Hydrogen peroxide ; Hydrogen Peroxide - pharmacology ; Norovirus ; Norovirus - drug effects ; Norovirus - physiology ; Oxides - pharmacology ; Peracetic Acid - pharmacology ; Peroxyacetic acid ; Phosphates - pharmacology ; Sodium Hypochlorite - pharmacology ; Time ; Trisodium phosphate ; Virus Inactivation</subject><ispartof>International journal of food microbiology, 2014-02, Vol.171, p.94-99</ispartof><rights>2013</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-2efa6ceb7ba3ea61cbb4078d9a08e7f8d373e4f988c0f6eaa411aa25578a82fc3</citedby><cites>FETCH-LOGICAL-c506t-2efa6ceb7ba3ea61cbb4078d9a08e7f8d373e4f988c0f6eaa411aa25578a82fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28296302$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24334094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kingsley, David H.</creatorcontrib><creatorcontrib>Vincent, Emily M.</creatorcontrib><creatorcontrib>Meade, Gloria K.</creatorcontrib><creatorcontrib>Watson, Clytrice L.</creatorcontrib><creatorcontrib>Fan, Xuetong</creatorcontrib><title>Inactivation of human norovirus using chemical sanitizers</title><title>International journal of food microbiology</title><addtitle>Int J Food Microbiol</addtitle><description>The porcine gastric mucin binding magnetic bead (PGM-MB) assay was used to evaluate the ability of chlorine, chlorine dioxide, peroxyacetic acid, hydrogen peroxide, and trisodium phosphate to inactivate human norovirus within 10% stool filtrate. One-minute free chlorine treatments at concentrations of 33 and 189ppm reduced virus binding in the PGM-MB assay by 1.48 and 4.14 log10, respectively, suggesting that chlorine is an efficient sanitizer for inactivation of human norovirus (HuNoV). Five minute treatments with 5% trisodium phosphate (pH~12) reduced HuNoV binding by 1.6 log10, suggesting that TSP, or some other high pH buffer, could be used to treat food and food contact surfaces to reduce HuNoV. One minute treatments with 350ppm chlorine dioxide dissolved in water did not reduce PGM-MB binding, suggesting that the sanitizer may not be suitable for HuNoV inactivation in liquid form. However a 60-min treatment with 350ppm chlorine dioxide did reduce human norovirus by 2.8 log10, indicating that chlorine dioxide had some, albeit limited, activity against HuNoV. Results also suggest that peroxyacetic acid has limited effectiveness against human norovirus, since 1-min treatments with up to 195ppm reduced human norovirus binding by <1 log10. Hydrogen peroxide (4%) treatment of up to 60min resulted in minimal binding reduction (~0.1 log10) suggesting that H2O2 is not a good liquid sanitizer for HuNoV. Overall this study suggests that HuNoV is remarkably resistant to several commonly used disinfectants and advocates for the use of chlorine (sodium hypochlorite) as a HuNoV disinfectant wherever possible.
•Human noroviruses (HuNoVs) interact with porcine gastric mucins (PGMs).•Inactivated HuNoVs do not interact with PGMs due to capsid damage.•PGM binding has been used to evaluate norovirus inactivation by chemical sanitizers.•HuNoV appears to be highly resistant to many common sanitizers.</description><subject>Biological and medical sciences</subject><subject>Caliciviridae Infections - prevention & control</subject><subject>Chlorine</subject><subject>Chlorine - pharmacology</subject><subject>Chlorine Compounds - pharmacology</subject><subject>Chlorine dioxide</subject><subject>Disinfectants - pharmacology</subject><subject>Food industries</subject><subject>Food microbiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human norovirus</subject><subject>Humans</subject><subject>Hydrogen peroxide</subject><subject>Hydrogen Peroxide - pharmacology</subject><subject>Norovirus</subject><subject>Norovirus - drug effects</subject><subject>Norovirus - physiology</subject><subject>Oxides - pharmacology</subject><subject>Peracetic Acid - pharmacology</subject><subject>Peroxyacetic acid</subject><subject>Phosphates - pharmacology</subject><subject>Sodium Hypochlorite - pharmacology</subject><subject>Time</subject><subject>Trisodium phosphate</subject><subject>Virus Inactivation</subject><issn>0168-1605</issn><issn>1879-3460</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqN0MFu1DAQgGELgei28AooHJC4JIxjJ7GPaFXaSpW4wNmaOGPq1cYudrISfXpc7VJ6g5Mv38xYP2PvOTQceP9p1_idi3GavU2xaYGLhvMGuHrBNlwNuhayh5dsU6yqeQ_dGTvPeQcAnRDwmp21UggJWm6YvgloF3_AxcdQRVfdrTOGKsQUDz6tuVqzDz8qe0flGO6rjMEv_oFSfsNeOdxnent6L9j3L5ffttf17derm-3n29p20C91Sw57S-MwoiDsuR1HCYOaNIKiwalJDIKk00pZcD0hSs4R264bFKrWWXHBPh733qf4c6W8mNlnS_s9BoprNryDso8PXPybSl2oBKkL1UdaCuacyJn75GdMvwwH8xjZ7MyzyOYxsuHclMhl9t3pzDrOND1N_qlawIcTwFyiuYTB-vzXqVb3AtritkdHpd_BUzLZegqWJp_ILmaK_j--8xszY6Eg</recordid><startdate>20140203</startdate><enddate>20140203</enddate><creator>Kingsley, David H.</creator><creator>Vincent, Emily M.</creator><creator>Meade, Gloria K.</creator><creator>Watson, Clytrice L.</creator><creator>Fan, Xuetong</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>20140203</creationdate><title>Inactivation of human norovirus using chemical sanitizers</title><author>Kingsley, David H. ; Vincent, Emily M. ; Meade, Gloria K. ; Watson, Clytrice L. ; Fan, Xuetong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-2efa6ceb7ba3ea61cbb4078d9a08e7f8d373e4f988c0f6eaa411aa25578a82fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biological and medical sciences</topic><topic>Caliciviridae Infections - prevention & control</topic><topic>Chlorine</topic><topic>Chlorine - pharmacology</topic><topic>Chlorine Compounds - pharmacology</topic><topic>Chlorine dioxide</topic><topic>Disinfectants - pharmacology</topic><topic>Food industries</topic><topic>Food microbiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human norovirus</topic><topic>Humans</topic><topic>Hydrogen peroxide</topic><topic>Hydrogen Peroxide - pharmacology</topic><topic>Norovirus</topic><topic>Norovirus - drug effects</topic><topic>Norovirus - physiology</topic><topic>Oxides - pharmacology</topic><topic>Peracetic Acid - pharmacology</topic><topic>Peroxyacetic acid</topic><topic>Phosphates - pharmacology</topic><topic>Sodium Hypochlorite - pharmacology</topic><topic>Time</topic><topic>Trisodium phosphate</topic><topic>Virus Inactivation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kingsley, David H.</creatorcontrib><creatorcontrib>Vincent, Emily M.</creatorcontrib><creatorcontrib>Meade, Gloria K.</creatorcontrib><creatorcontrib>Watson, Clytrice L.</creatorcontrib><creatorcontrib>Fan, Xuetong</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>International journal of food microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kingsley, David H.</au><au>Vincent, Emily M.</au><au>Meade, Gloria K.</au><au>Watson, Clytrice L.</au><au>Fan, Xuetong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inactivation of human norovirus using chemical sanitizers</atitle><jtitle>International journal of food microbiology</jtitle><addtitle>Int J Food Microbiol</addtitle><date>2014-02-03</date><risdate>2014</risdate><volume>171</volume><spage>94</spage><epage>99</epage><pages>94-99</pages><issn>0168-1605</issn><eissn>1879-3460</eissn><coden>IJFMDD</coden><abstract>The porcine gastric mucin binding magnetic bead (PGM-MB) assay was used to evaluate the ability of chlorine, chlorine dioxide, peroxyacetic acid, hydrogen peroxide, and trisodium phosphate to inactivate human norovirus within 10% stool filtrate. One-minute free chlorine treatments at concentrations of 33 and 189ppm reduced virus binding in the PGM-MB assay by 1.48 and 4.14 log10, respectively, suggesting that chlorine is an efficient sanitizer for inactivation of human norovirus (HuNoV). Five minute treatments with 5% trisodium phosphate (pH~12) reduced HuNoV binding by 1.6 log10, suggesting that TSP, or some other high pH buffer, could be used to treat food and food contact surfaces to reduce HuNoV. One minute treatments with 350ppm chlorine dioxide dissolved in water did not reduce PGM-MB binding, suggesting that the sanitizer may not be suitable for HuNoV inactivation in liquid form. However a 60-min treatment with 350ppm chlorine dioxide did reduce human norovirus by 2.8 log10, indicating that chlorine dioxide had some, albeit limited, activity against HuNoV. Results also suggest that peroxyacetic acid has limited effectiveness against human norovirus, since 1-min treatments with up to 195ppm reduced human norovirus binding by <1 log10. Hydrogen peroxide (4%) treatment of up to 60min resulted in minimal binding reduction (~0.1 log10) suggesting that H2O2 is not a good liquid sanitizer for HuNoV. Overall this study suggests that HuNoV is remarkably resistant to several commonly used disinfectants and advocates for the use of chlorine (sodium hypochlorite) as a HuNoV disinfectant wherever possible.
•Human noroviruses (HuNoVs) interact with porcine gastric mucins (PGMs).•Inactivated HuNoVs do not interact with PGMs due to capsid damage.•PGM binding has been used to evaluate norovirus inactivation by chemical sanitizers.•HuNoV appears to be highly resistant to many common sanitizers.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>24334094</pmid><doi>10.1016/j.ijfoodmicro.2013.11.018</doi><tpages>6</tpages></addata></record> |
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| ispartof | International journal of food microbiology, 2014-02, Vol.171, p.94-99 |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Biological and medical sciences Caliciviridae Infections - prevention & control Chlorine Chlorine - pharmacology Chlorine Compounds - pharmacology Chlorine dioxide Disinfectants - pharmacology Food industries Food microbiology Fundamental and applied biological sciences. Psychology Human norovirus Humans Hydrogen peroxide Hydrogen Peroxide - pharmacology Norovirus Norovirus - drug effects Norovirus - physiology Oxides - pharmacology Peracetic Acid - pharmacology Peroxyacetic acid Phosphates - pharmacology Sodium Hypochlorite - pharmacology Time Trisodium phosphate Virus Inactivation |
| title | Inactivation of human norovirus using chemical sanitizers |
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