C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma

Members of the nuclear factor-κB (NF-κB) family of transcriptional regulators are central mediators of the cellular inflammatory response. Although constitutive NF-κB signalling is present in most human tumours, mutations in pathway members are rare, complicating efforts to understand and block aber...

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Published in:	Nature (London) 2014-02, Vol.506 (7489), p.451-455
Main Authors:	Parker, Matthew, Mohankumar, Kumarasamypet M., Punchihewa, Chandanamali, Weinlich, Ricardo, Dalton, James D., Li, Yongjin, Lee, Ryan, Tatevossian, Ruth G., Phoenix, Timothy N., Thiruvenkatam, Radhika, White, Elsie, Tang, Bo, Orisme, Wilda, Gupta, Kirti, Rusch, Michael, Chen, Xiang, Li, Yuxin, Nagahawhatte, Panduka, Hedlund, Erin, Finkelstein, David, Wu, Gang, Shurtleff, Sheila, Easton, John, Boggs, Kristy, Yergeau, Donald, Vadodaria, Bhavin, Mulder, Heather L., Becksfort, Jared, Gupta, Pankaj, Huether, Robert, Ma, Jing, Song, Guangchun, Gajjar, Amar, Merchant, Thomas, Boop, Frederick, Smith, Amy A., Ding, Li, Lu, Charles, Ochoa, Kerri, Zhao, David, Fulton, Robert S., Fulton, Lucinda L., Mardis, Elaine R., Wilson, Richard K., Downing, James R., Green, Douglas R., Zhang, Jinghui, Ellison, David W., Gilbertson, Richard J.
Format:	Article
Language:	English
Subjects:	45/100 45/23 45/61 45/77 59/5 631/67/1922 631/67/68 64/60 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Base Sequence Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Cancer Carcinogenesis Cell Line Cell Nucleus - metabolism Cell Transformation, Neoplastic - genetics Chromosomes, Human, Pair 11 - genetics Ependymoma - genetics Ependymoma - metabolism Ependymoma - pathology Female Genetic regulation Gliomas Humanities and Social Sciences Humans Mice Models, Genetic Molecular Sequence Data multidisciplinary Neural Stem Cells - metabolism Neural Stem Cells - pathology NF-kappa B - genetics NF-kappa B - metabolism Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Oncogenes Oncology, Experimental Phosphoproteins - genetics Phosphoproteins - metabolism Proteins - genetics Proteins - metabolism Science Signal Transduction Transcription Factor RelA - genetics Transcription Factor RelA - metabolism Transcription Factors Translocation, Genetic - genetics
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