Preliminary results of multicenter questionnaire study on long-term outcomes of curative endoscopic submucosal dissection for early gastric cancer

• Published in: Digestive endoscopy 2014-03, Vol.26 (2), p.214-219
• Main Authors: Oda, Ichiro, Oyama, Tsuneo, Abe, Seiichiro, Ohnita, Ken, Kosaka, Takashi, Hirasawa, Kingo, Ishido, Kenji, Nakagawa, Masahiro, Takahashi, Shin'ichi
• Format: Article
• Language: English
• Subjects: Cause of Death - trends; curative resection; Dissection - methods; early gastric cancer; endoscopic submucosal dissection (ESD); Endoscopy, Gastrointestinal - methods; expanded indication; Follow-Up Studies; Gastric Mucosa - pathology; Gastric Mucosa - surgery; Humans; Japan - epidemiology; long-term outcome; Neoplasm Staging; Retrospective Studies; Stomach Neoplasms - diagnosis; Stomach Neoplasms - mortality; Stomach Neoplasms - surgery; Surveys and Questionnaires; Survival Rate - trends; Time Factors; Treatment Outcome
• ISSN: 0915-5635; 1443-1661
• DOI: 10.1111/den.12141

Background and Aim There are a number of published reports on long‐term outcomes of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC), but most reports are from single centers with median follow‐up periods shorter than 5 years. This questionnaire study investigated long‐term outcomes of curative ESD for EGC at six Japanese institutions with follow‐up rates of at least 90% over a minimum 5‐year period. Methods All consecutive patients with initial‐onset EGC who underwent ESD through December 2006 at the six institutions were included in our study. The questionnaire covered pathological curability and long‐term outcomes of patients with curative resections or curative resections for expanded indications over follow‐up periods of at least 5 years. Results There were 3788 patients with initial‐onset EGC including 1710 (45.1%) patients with curative resections and 1289 (34.0%) patients with curative resections for expanded indications. The remaining 789 (20.8%) patients had non‐curativeresections. Altogether, 1601 (93.6%) patients with curative resections and 1205 (93.5%) patients with curative resections for expanded indications were successfully followed up for at least 5 years. No recurrences were reported in any of the 1601 patients with curative resections whereas three recurrences (0.2%) were reported in the 1205 patients with curative resections for expanded indications. Gastric cancer‐related deaths occurred in seven (0.2%) of the 2806 patients with curative resections or curative resections for expanded indications including six patients with metachronous gastric cancer‐related deaths. Conclusion This questionnaire study's results indicated favorable long‐term outcomes for patients with curative resections or curative resections for expanded indications.