Characteristics of Sebaceous Carcinoma and Early Outcomes of Treatment Using Mohs Micrographic Surgery Versus Wide Local Excision: An Update of the Mayo Clinic Experience Over the Past 2 Decades

• Published in: Dermatologic surgery 2014-03, Vol.40 (3), p.241-246
• Main Authors: Hou, Jennifer L., Killian, Jill M., Baum, Christian L., Otley, Clark C., Roenigk, Randall K., Arpey, Christopher J., Weaver, Amy L., Brewer, Jerry D.
• Format: Article
• Language: English
• Subjects: Adenocarcinoma, Sebaceous - pathology; Adenocarcinoma, Sebaceous - surgery; Aged; Disease-Free Survival; Female; Humans; Male; Mohs Surgery; Retrospective Studies; Skin Neoplasms - pathology; Skin Neoplasms - surgery; Treatment Outcome
• ISSN: 1076-0512; 1524-4725
• DOI: 10.1111/dsu.12433

Background Sebaceous carcinoma (SC) is a rare cutaneous neoplasm. Objective To characterize SC and treatment approaches and outcomes. Methods and Materials We retrospectively reviewed records of patients with SC from 1992 through 2012. Recurrence‐free survival was estimated and compared between groups. Results We identified 52 patients with SC (39, 75.0% male). Mean age ± standard deviation at diagnosis was 72.7 ± 10.8. Forty‐nine patients (94.2%) were white. Twenty‐one (of 29 with known status) had a diagnosis of Muir‐Torre syndrome. Six had multiple primary SCs (total of 73 SCs in 52 patients). The most common locations for SC were the back (20.5%), cheek (13.7%), nose (11.0%), and eye (9.6%). Treatment was recorded for 70 SCs; 35 (50.0%) were treated using Mohs micrographic surgery (MMS) and 26 (37.1%) using wide local excision (WLE). Of the 45 patients (66 SCs) with clinical follow‐up, three (6.7% of patients; 4.8% of SCs) had documented recurrence. Conclusion MMS and WLE are effective treatments for SC. Further research is warranted to determine whether one treatment is more efficacious than the other.