Transcutaneous electrical nerve stimulation as a novel method of remote preconditioning: in vitro validation in an animal model and first human observations

Remote ischemic preconditioning (rIPC) induced by transient limb ischemia (li-rIPC) leads to neurally dependent release of blood-borne factors that provide potent cardioprotection. We hypothesized that transcutaneous electrical nerve stimulation (TENS) is a clinically relevant stimulus of rIPC. Stud...

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Bibliographic Details
Published in:Basic research in cardiology 2014-05, Vol.109 (3), p.406-406, Article 406
Main Authors: Merlocco, Anthony C., Redington, Kathrine L., Disenhouse, Tara, Strantzas, Samuel C., Gladstone, Rachel, Wei, Can, Tropak, Michael B., Manlhiot, Cedric, Li, Jing, Redington, Andrew N.
Format: Article
Language:English
Subjects:
Adult
Animals
Biomarkers - blood
Cardiology
Disease Models, Animal
Female
Hindlimb - blood supply
Humans
Ischemic Preconditioning - methods
Male
Medicine
Medicine & Public Health
Mice
Mice, Inbred C57BL
Myocardial Infarction - blood
Myocardial Infarction - pathology
Myocardial Infarction - physiopathology
Myocardial Infarction - prevention & control
Myocardial Reperfusion Injury - blood
Myocardial Reperfusion Injury - pathology
Myocardial Reperfusion Injury - physiopathology
Myocardial Reperfusion Injury - prevention & control
Myocardium - metabolism
Myocardium - pathology
Narcotic Antagonists - pharmacology
Original Contribution
Rabbits
Regional Blood Flow
Time Factors
Transcutaneous Electric Nerve Stimulation
Upper Extremity - blood supply
Ventricular Function, Left
Ventricular Pressure
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Summary:Remote ischemic preconditioning (rIPC) induced by transient limb ischemia (li-rIPC) leads to neurally dependent release of blood-borne factors that provide potent cardioprotection. We hypothesized that transcutaneous electrical nerve stimulation (TENS) is a clinically relevant stimulus of rIPC. Study 1: seven rabbits were subjected to lower limb TENS; six to li-rIPC, and six to sham intervention. Blood was drawn and used to prepare a dialysate for subsequent analysis of cardioprotection in rabbit Langendorff preparation. Study 2: 14 healthy adults underwent upper limb TENS stimulation on one study day, 10 of whom also underwent li-rIPC on another study day. Blood was drawn before and after each stimulus, dialysate prepared, and cardioprotective activity assessed in mouse Langendorff preparation. The infarct size and myocardial recovery were measured after 30 min of global ischemia and 60 or 120 min of reperfusion. Animal validation: compared to control, TENS induced marked cardioprotection with significantly reduced infarct size (TENS vs. sham p  
ISSN:0300-8428
1435-1803
DOI:10.1007/s00395-014-0406-0