Correlation of Neutrophil to Lymphocyte Ratio With the Presence and Severity of Metabolic Syndrome

Purpose: The aim of this study is to investigate the relationship between the criteria comprising metabolic syndrome (MS) and neutrophil–lymphocyte ratio (NLR), a simple and reliable indicator of inflammation. Method: Seventy patients with MS and 71 age- and sex-matched control participants were inc...

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Bibliographic Details
Published in:Clinical and applied thrombosis/hemostasis 2014-03, Vol.20 (2), p.159-163
Main Authors: Buyukkaya, Eyup, Karakaş, Mehmet Fatih, Karakaş, Esra, Akçay, Adnan Burak, Tanboga, Ibrahim Halil, Kurt, Mustafa, Sen, Nihat
Format: Article
Language:English
Subjects:
C-Reactive Protein - immunology
Case-Control Studies
Female
Humans
Inflammation - blood
Lymphocytes - immunology
Lymphocytes - pathology
Male
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - classification
Middle Aged
Neutrophils
Neutrophils - immunology
Neutrophils - pathology
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Summary:Purpose: The aim of this study is to investigate the relationship between the criteria comprising metabolic syndrome (MS) and neutrophil–lymphocyte ratio (NLR), a simple and reliable indicator of inflammation. Method: Seventy patients with MS and 71 age- and sex-matched control participants were included. Patients were classified into 3 groups based on the number of MS criteria: group 1 (with 3 criteria), group 2 (with 4 criteria), and group 3 (with 5 criteria). The NLR was calculated from complete blood count. Results: Patients with MS had significantly higher NLR compared to the control group. Moreover, the group 3 patients had higher NLR than those in groups 2 and 1 (P = .008 and P = .078, respectively), whereas there was no difference between the patients meeting 3 and 4 MS criteria (P = .320). Besides, NLR increased as the severity of MS increased (r = .586, P < .001). The cutoff level for NLR with optimal sensitivity and specificity was calculated as 1.84. Serum glucose and high-sensitive C-reactive protein level were found to be independent predictors of an NLR value greater than 1.84. Conclusion: The present study indicated a significant correlation between the criteria of MS and inflammation on the basis of NLR. Furthermore, there an increase in NLR as the severity of MS increases.
ISSN:1076-0296
1938-2723
DOI:10.1177/1076029612459675