Safety of non-anaesthesiologist-administered propofol sedation in ERCP

• Published in: Arab journal of gastroenterology 2014-03, Vol.15 (1), p.32-35
• Main Authors: Khan, Haider Ali, Umar, Muhammad, tul-Bushra, Hamama, Nisar, Gul, Bilal, Muhammad, Umar, Shifa
• Format: Article
• Language: English
• Subjects: Adult; Advanced Cardiac Life Support - education; Aged; Anesthesiology; Certification; Cholangiopancreatography, Endoscopic Retrograde; Deep Sedation - adverse effects; Deep Sedation - methods; Education, Medical, Continuing; Endoscopic retrograde cholangiopancreatography (ERCP); Female; Health Status; Health Status Indicators; Humans; Hypnotics and Sedatives - administration & dosage; Hypnotics and Sedatives - adverse effects; Male; Middle Aged; Non-anaesthesiologist administered propofol (NAAP); Physician's Role; Propofol; Propofol - administration & dosage; Propofol - adverse effects; Respiration, Artificial
• ISSN: 1687-1979; 2090-2387
• DOI: 10.1016/j.ajg.2014.01.011

Propofol is increasingly being used for sedation purposes during endoscopic retrograde cholangiopancreatography (ERCP). This study aimed to evaluate the safety of non-anaesthesiologist administration of propofol (NAAP) during therapeutic ERCP. Patients, who underwent ERCP at Centre for Liver and Digestive Diseases, Holy Family Hospital, Rawalpindi, were included in the study. Propofol sedation was administered by a physician who was a non-anaesthesiologist certified in basic and advanced cardiac life support. The total study duration was 6months. The primary outcome variable was the frequency of any sedation-related complication. A total of 156 patients (41% males and 59% females) were enrolled in the study. The mean propofol dose used during the procedure was 201±132mg. The mean propofol dose, when adjusted to weight and duration of procedure, was 0.05±0.04mgkg−1min−1. According to the American Society of Anesthesiologists (ASA) classification, 136 (87%) patients were placed in ASA class I and II and 20 (13%) patients were of ASA class III. Only two patients developed sedation-related complication: one minor requiring bag-mask ventilation and other major requiring mechanical ventilation via endotracheal intubation. Both were managed by the trained non-anaesthesiologist and gastroenterologist at the place of procedure. No patients required cardiopulmonary resuscitation and admission to the intensive care unit. There were no sedation-related deaths. NAAP sedation can be considered safe for low-risk patients (ASA class I and II) undergoing ERCP. The presence of a trained anaesthetist is advisable in high-risk patients (ASA class III and higher) with significant co-morbidities.