Effects of sleep fragmentation on appetite and related hormone concentrations over 24 h in healthy men

In addition to short sleep duration, reduced sleep quality is also associated with appetite control. The present study examined the effect of sleep fragmentation, independent of sleep duration, on appetite profiles and 24 h profiles of hormones involved in energy balance regulation. A total of twelv...

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Bibliographic Details
Published in:British journal of nutrition 2013-02, Vol.109 (4), p.748-756
Main Authors: Gonnissen, Hanne K. J., Hursel, Rick, Rutters, Femke, Martens, Eveline A. P., Westerterp-Plantenga, Margriet S.
Format: Article
Language:English
Subjects:
Adult
Appetite - physiology
Appetite Regulation
Behaviour, Appetite and Obesity
Biological and medical sciences
Blood Glucose - analysis
Eating
Energy balance
Energy Metabolism
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Ghrelin - blood
Glucagon-Like Peptide 1 - blood
Healthy Volunteers
Hormones
Hormones - blood
Humans
Hydrocortisone - blood
Insulin - blood
Insulin - metabolism
Insulin Secretion
Leptin - blood
Male
Melatonin - blood
Mens health
Nutrition research
Obesity
Polysomnography
Sleep
Sleep - physiology
Sleep Deprivation - blood
Sleep, REM - physiology
Surveys and Questionnaires
Time Factors
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Young Adult
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Summary:In addition to short sleep duration, reduced sleep quality is also associated with appetite control. The present study examined the effect of sleep fragmentation, independent of sleep duration, on appetite profiles and 24 h profiles of hormones involved in energy balance regulation. A total of twelve healthy male subjects (age 23 (sd 4) years, BMI 24·4 (sd 1·9) kg/m2) completed a 24 h randomised crossover study in which sleep (23.30–07.30 hours) was either fragmented or non-fragmented. Polysomnography was used to determine rapid-eye movement (REM) sleep, slow-wave sleep (SWS) and total sleep time (TST). Blood samples were taken at baseline and continued hourly for the 24 h period to measure glucose, insulin, ghrelin, leptin, glucagon-like peptide 1 (GLP-1) and melatonin concentrations. In addition, salivary cortisol levels were measured. Visual analogue scales were used to score appetite-related feelings. Sleep fragmentation resulted in reduced REM sleep (69·4 min compared with 83·5 min; P
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114512001894