Changes in sleep and wakefulness following single and repeated exposures to toluene vapor in rats

Male rats with indwelling electrodes for electroencephalographic (EEG), electromyographic (EMG) and electrooculographic (EOG) recordings were exposed via inhalation to 900 ppm and 2700 ppm toluene vapor continuously for a 8-h period or repeatedly for 3 weeks at a rate of 8 h/day and 5 days/week. Rat...

Full description

Saved in:
Bibliographic Details
Published in:Archives of toxicology 1988-08, Vol.62 (1), p.76-80
Main Authors: ARITO, H, TSURUTA, H, OGURI, M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain Chemistry - drug effects
Chemical and industrial products toxicology. Toxic occupational diseases
Electrodes, Implanted - veterinary
Electroencephalography
Electromyography
Electrooculography
Male
Medical sciences
Rats
Rats, Inbred Strains
Sleep Stages - drug effects
Sleep, REM - drug effects
Solvents
Toluene - toxicity
Toxicology
Wakefulness - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Male rats with indwelling electrodes for electroencephalographic (EEG), electromyographic (EMG) and electrooculographic (EOG) recordings were exposed via inhalation to 900 ppm and 2700 ppm toluene vapor continuously for a 8-h period or repeatedly for 3 weeks at a rate of 8 h/day and 5 days/week. Rats exposed to a clean air-stream under the same exposure schedules served as controls. Polygraphic recordings were made on 3 consecutive days after cessation of the single 8-h and repeated 3-week exposures to 900 ppm and 2700 ppm toluene vapor or clean airstream. Amounts of time spent in wakefulness (W), slow-wave sleep (SWS) and paradoxical sleep (PS) were quantified by visual inspection of the polygraphic records. Single exposure to toluene produced a prolonged PS latency and a long-lasting increase in SWS at the expense of depressed W, whereas repeated exposures prolonged both SWS and PS latencies, abolished the initial increase of SWS and increased the light-phase level of W on Days 1 and 2. The prolonged PS latency and the decreased light-phase PS on Day 2 induced by single exposure to toluene still persisted after repeated exposures. There were no statistically significant differences in attenuation of brain and blood toluene levels between single and repeated exposures to toluene vapor of 900 ppm and 2700 ppm.
ISSN:0340-5761
1432-0738
DOI:10.1007/BF00316262