Performance of a third-generation TSH-receptor antibody in a UK clinic

Summary Background  UK national guidelines recommend the measurement of TSH receptor antibodies (TRAb) in certain clinical scenarios. A commercial third‐generation TRAb autoantibody M22‐biotin ELISA assay was introduced in May 2008 in our centre. Objective  To evaluate the diagnostic performance of...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2011-07, Vol.75 (1), p.127-133
Main Authors: Theodoraki, A., Jones, G., Parker, J., Woolman, E., Martin, N., Perera, S., Thomas, M., Bunn, C., Khoo, B., Bouloux, P. M., Vanderpump, M. P. J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal
Biological and medical sciences
Child
Cost control
Endocrinopathies
Enzyme-Linked Immunosorbent Assay - standards
Female
Fundamental and applied biological sciences. Psychology
Graves Disease - diagnosis
Humans
Hyperthyroidism
Immunoglobulins, Thyroid-Stimulating
Male
Medical research
Medical sciences
Middle Aged
Receptors, Thyrotropin - immunology
Sensitivity and Specificity
Thyroid Diseases - diagnosis
United Kingdom
Vertebrates: endocrinology
Young Adult
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Summary:Summary Background  UK national guidelines recommend the measurement of TSH receptor antibodies (TRAb) in certain clinical scenarios. A commercial third‐generation TRAb autoantibody M22‐biotin ELISA assay was introduced in May 2008 in our centre. Objective  To evaluate the diagnostic performance of a TRAb assay in a retrospective and subsequently a prospective cohort in a UK centre. Design  A retrospective review of patients with thyroid disease followed by a prospective observational study in consecutive patients with newly found suppressed serum thyrotrophin (TSH). Patients and Measurements  Medical records of 200 consecutive patients with thyroid disorders who had TRAb measured since the introduction of the assay. In a prospective study 44 patients with newly identified hyperthyroidism (TSH 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2011.04022.x