A Bacterial Tyrosine Phosphatase Inhibits Plant Pattern Recognition Receptor Activation

Innate immunity relies on the perception of pathogen-associated molecular patterns (PAMPs) by pattern-recognition receptors (PRRs) located on the host cell's surface. Many plant PRRs are kinases. Here, we report that the Arabidopsis receptor kinase EF-TU RECEPTOR (EFR), which perceives the elf1...

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Published in:Science (American Association for the Advancement of Science) 2014-03, Vol.343 (6178), p.1509-1512
Main Authors: Macho, Alberto P., Schwessinger, Benjamin, Ntoukakis, Vardis, Brutus, Alexandre, Segonzac, Cécile, Roy, Sonali, Kadota, Yasuhiro, Oh, Man-Ho, Sklenar, Jan, Derbyshire, Paul, Lozano-Durán, Rosa, Malinovsky, Frederikke Gro, Monaghan, Jacqueline, Menke, Frank L., Huber, Steven C., He, Sheng Yang, Zipfel, Cyril
Format: Article
Language:English
Subjects:
Arabidopsis - immunology
Arabidopsis - microbiology
Arabidopsis Proteins - agonists
Arabidopsis Proteins - metabolism
Bacteria
Bacterial Proteins - metabolism
Enzymes
Immunity
Molecular biology
Parent teacher organizations
Pattern Recognition
Peptide Elongation Factor Tu - metabolism
Peptides - metabolism
Peptides - pharmacology
Phosphatases
Phosphorylation
Plant biology
Pretreatment
Protein Tyrosine Phosphatases - metabolism
Pseudomonas syringae - enzymology
Pseudomonas syringae - pathogenicity
Receptors
Receptors, Pattern Recognition - agonists
Receptors, Pattern Recognition - metabolism
Seedlings
Solvents
Tyrosine - metabolism
Virulence
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Summary:Innate immunity relies on the perception of pathogen-associated molecular patterns (PAMPs) by pattern-recognition receptors (PRRs) located on the host cell's surface. Many plant PRRs are kinases. Here, we report that the Arabidopsis receptor kinase EF-TU RECEPTOR (EFR), which perceives the elf18 peptide derived from bacterial elongation factor Tu, is activated upon ligand binding by phosphorylation on its tyrosine residues. Phosphorylation of a single tyrosine residue, Y836, is required for activation of EFR and downstream immunity to the phytopathogenic bacterium Pseudomonas syringae. A tyrosine phosphatase, HopAO1, secreted by P. syringae, reduces EFR phosphorylation and prevents subsequent immune responses. Thus, host and pathogen compete to take control of PRR tyrosine phosphorylation used to initiate antibacterial immunity.
ISSN:0036-8075
1095-9203
1095-9203
DOI:10.1126/science.1248849