Facial emotion perception differs in young persons at genetic and clinical high-risk for psychosis

• Published in: Psychiatry research 2014-05, Vol.216 (2), p.206-212
• Main Authors: Kohler, Christian G, Richard, Jan A, Brensinger, Colleen M, Borgmann-Winter, Karin E, Conroy, Catherine G, Moberg, Paul J, Gur, Ruben C, Gur, Raquel E, Calkins, Monica E
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Adult and adolescent clinical studies; Anger; Biological and medical sciences; Clinical high-risk for psychosis; Emotion differentiation; Emotion recognition; Emotions; Facial Expression; Fear; Female; Genetic Predisposition to Disease; Genetic risk; Happiness; Humans; Male; Medical sciences; Perception; Psychiatric Status Rating Scales; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Psychotic Disorders - diagnosis; Psychotic Disorders - genetics; Psychotic Disorders - psychology; Recognition (Psychology); Risk Factors; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - genetics; Schizophrenic Psychology; Young Adult
• ISSN: 0165-1781; 1872-7123
• DOI: 10.1016/j.psychres.2014.01.023

Abstract A large body of literature has documented facial emotion perception impairments in schizophrenia. More recently, emotion perception has been investigated in persons at genetic and clinical high-risk for psychosis. This study compared emotion perception abilities in groups of young persons with schizophrenia, clinical high-risk, genetic risk and healthy controls. Groups, ages 13–25, included 24 persons at clinical high-risk, 52 first-degree relatives at genetic risk, 91 persons with schizophrenia and 90 low risk persons who completed computerized testing of emotion recognition and differentiation. Groups differed by overall emotion recognition abilities and recognition of happy, sad, anger and fear expressions. Pairwise comparisons revealed comparable impairments in recognition of happy, angry, and fearful expressions for persons at clinical high-risk and schizophrenia, while genetic risk participants were less impaired, showing reduced recognition of fearful expressions. Groups also differed for differentiation of happy and sad expressions, but differences were mainly between schizophrenia and control groups. Emotion perception impairments are observable in young persons at-risk for psychosis. Preliminary results with clinical high-risk participants, when considered along findings in genetic risk relatives, suggest social cognition abilities to reflect pathophysiological processes involved in risk of schizophrenia.