Vibrational spectroscopy of biofluids for disease screening or diagnosis: translation from the laboratory to a clinical setting

There remains a need for objective and cost‐effective approaches capable of diagnosing early‐stage disease in point‐of‐care clinical settings. Given an increasingly ageing population resulting in a rising prevalence of chronic diseases, the need for screening to facilitate the personalising of thera...

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Bibliographic Details
Published in:Journal of biophotonics 2014-04, Vol.7 (3-4), p.153-165
Main Authors: Mitchell, Alana L., Gajjar, Ketan B., Theophilou, Georgios, Martin, Francis L., Martin-Hirsch, Pierre L.
Format: Article
Language:English
Subjects:
ATR-FTIR spectroscopy
biofluid
biomarkers
Biomarkers - analysis
Diabetes Mellitus - diagnosis
Equipment Design
Humans
Microfluidic Analytical Techniques
microfluidic platform
Neoplasms - diagnosis
Neurodegenerative Diseases - diagnosis
point-of-care
Point-of-Care Systems
Raman spectroscopy
screening
Spectrophotometry, Infrared - methods
Spectroscopy, Fourier Transform Infrared - methods
Spectrum Analysis, Raman - methods
Vibration
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Summary:There remains a need for objective and cost‐effective approaches capable of diagnosing early‐stage disease in point‐of‐care clinical settings. Given an increasingly ageing population resulting in a rising prevalence of chronic diseases, the need for screening to facilitate the personalising of therapies to prevent or slow down pathology development will increase. Such a tool needs to be robust but simple enough to be implemented into clinical practice. There is interest in extracting biomarkers from biofluids (e.g., plasma or serum); techniques based on vibrational spectroscopy provide an option. Sample preparation is minimal, techniques involved are relatively low‐cost, and data frameworks are available. This review explores the evidence supporting the applicability of vibrational spectroscopy to generate spectral biomarkers of disease in biofluids. We extend the inter‐disciplinary nature of this approach to hypothesise a microfluidic platform that could allow such measurements. With an appropriate lightsource, such engineering could revolutionize screening in the 21st century. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
ISSN:1864-063X
1864-0648
DOI:10.1002/jbio.201400018