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Longitudinal changes in high-density lipoprotein cholesterol and cardiovascular events in older adults

Summary Objective While low high‐density lipoprotein cholesterol (HDL‐C) is associated with increased risk of cardiovascular (CV) events, there are limited data evaluating the association of longitudinal change in HDL‐C with CV event risk in older populations. The aim of this study was to examine th...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2014-05, Vol.80 (5), p.662-670
Main Authors: Araujo, Andre B., Chiu, Gretchen R., Christian, Jennifer B., Kim, Hae Young, Evans, William J., Clark, Richard V.
Format: Article
Language:English
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Summary:Summary Objective While low high‐density lipoprotein cholesterol (HDL‐C) is associated with increased risk of cardiovascular (CV) events, there are limited data evaluating the association of longitudinal change in HDL‐C with CV event risk in older populations. The aim of this study was to examine the association between within‐subject changes in HDL‐C levels and CV events in an older population. Design Observational cohort study. Patients 1293 men and 1422 women age ≥50 years, with ≥2 consecutive HDL measurements, and no prior CVD as part of Framingham Offspring Study. Measurements A clinical CV event was defined as the first occurrence of any of the following: coronary heart disease (coronary death, myocardial infarction, coronary insufficiency and angina), cerebrovascular event, peripheral artery disease or heart failure. Results Median total follow‐up time across subjects was 9·6 years. Change in HDL‐C was evaluated as between‐exam (approximately 3·5 years) percentage change in HDL‐C, categorized as ≥10% decrease,
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.12212