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Longitudinal changes in high-density lipoprotein cholesterol and cardiovascular events in older adults
Summary Objective While low high‐density lipoprotein cholesterol (HDL‐C) is associated with increased risk of cardiovascular (CV) events, there are limited data evaluating the association of longitudinal change in HDL‐C with CV event risk in older populations. The aim of this study was to examine th...
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| Published in: | Clinical endocrinology (Oxford) 2014-05, Vol.80 (5), p.662-670 |
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| Main Authors: | , , , , , |
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| container_title | Clinical endocrinology (Oxford) |
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| creator | Araujo, Andre B. Chiu, Gretchen R. Christian, Jennifer B. Kim, Hae Young Evans, William J. Clark, Richard V. |
| description | Summary
Objective
While low high‐density lipoprotein cholesterol (HDL‐C) is associated with increased risk of cardiovascular (CV) events, there are limited data evaluating the association of longitudinal change in HDL‐C with CV event risk in older populations. The aim of this study was to examine the association between within‐subject changes in HDL‐C levels and CV events in an older population.
Design
Observational cohort study.
Patients
1293 men and 1422 women age ≥50 years, with ≥2 consecutive HDL measurements, and no prior CVD as part of Framingham Offspring Study.
Measurements
A clinical CV event was defined as the first occurrence of any of the following: coronary heart disease (coronary death, myocardial infarction, coronary insufficiency and angina), cerebrovascular event, peripheral artery disease or heart failure.
Results
Median total follow‐up time across subjects was 9·6 years. Change in HDL‐C was evaluated as between‐exam (approximately 3·5 years) percentage change in HDL‐C, categorized as ≥10% decrease, |
| doi_str_mv | 10.1111/cen.12212 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1514428477</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1514428477</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4212-c9e40bf1ef0c24a20e817a282611855e26e2f2c9b6dfc5fdb104cae00aaa4dc73</originalsourceid><addsrcrecordid>eNp1kc1uEzEURi0EoqGw4AXQSAipLKa1Pf6ZWULUBqSoZAFiaTn2ncTFsVN7pjRvj9OkRULCGy987nc_HSP0luBzUs6FgXBOKCX0GZqQRvCaUsGfowluMK6xEOwEvcr5BmPMWyxfohPacI7bjk1QP49h5YbRuqB9ZdY6rCBXLlRrt1rXFkJ2w67ybhu3KQ5QHsw6esgDpOgrHWxldLIu3ulsRq9TBXcQhoeE6C2kStvRD_k1etFrn-HN8T5FP64uv0-_1PNvs6_TT_PasFK_Nh0wvOwJ9NhQpimGlkhNWyoIaTkHKoD21HRLYXvDe7skmBkNGGutmTWyOUVnh9zS9nYsNdXGZQPe6wBxzIpwwhhtmdyj7_9Bb-KYioU9RQWVTEhaqI8HyqSYc4JebZPb6LRTBKu9fFXkqwf5hX13TByXG7BP5KPtAnw4AsWW9n3Swbj8l2ubrsGEF-7iwP12Hnb_36iml9ePq-vDhCs_c_80odMvJWQjufp5PVOfF7NusZBXat78Ada6qyE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1526274672</pqid></control><display><type>article</type><title>Longitudinal changes in high-density lipoprotein cholesterol and cardiovascular events in older adults</title><source>Wiley:Jisc Collections:Wiley Read and Publish Open Access 2024-2025 (reading list)</source><creator>Araujo, Andre B. ; Chiu, Gretchen R. ; Christian, Jennifer B. ; Kim, Hae Young ; Evans, William J. ; Clark, Richard V.</creator><creatorcontrib>Araujo, Andre B. ; Chiu, Gretchen R. ; Christian, Jennifer B. ; Kim, Hae Young ; Evans, William J. ; Clark, Richard V.</creatorcontrib><description>Summary
Objective
While low high‐density lipoprotein cholesterol (HDL‐C) is associated with increased risk of cardiovascular (CV) events, there are limited data evaluating the association of longitudinal change in HDL‐C with CV event risk in older populations. The aim of this study was to examine the association between within‐subject changes in HDL‐C levels and CV events in an older population.
Design
Observational cohort study.
Patients
1293 men and 1422 women age ≥50 years, with ≥2 consecutive HDL measurements, and no prior CVD as part of Framingham Offspring Study.
Measurements
A clinical CV event was defined as the first occurrence of any of the following: coronary heart disease (coronary death, myocardial infarction, coronary insufficiency and angina), cerebrovascular event, peripheral artery disease or heart failure.
Results
Median total follow‐up time across subjects was 9·6 years. Change in HDL‐C was evaluated as between‐exam (approximately 3·5 years) percentage change in HDL‐C, categorized as ≥10% decrease, <10% change (stable) and ≥10% increase. Crude and adjusted sex‐specific Cox hazards regression models with change in HDL‐C as a time‐dependent covariate quantified the association with CV events. Mean baseline age of the analysis sample was 53 years. There were 233 and 111 CV events among men and women, respectively. Change in HDL‐C was not significantly associated with CVD incidence in men or women, without or with adjustment for confounders including baseline HDL‐C or use of relevant medications.
Conclusion
In conclusion, relatively short‐term (3·5 years) changes in HDL‐C levels do not affect CV events in men and women.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.12212</identifier><identifier>PMID: 23550894</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject>Aged ; Aging ; Biological and medical sciences ; Cardiovascular disease ; Cardiovascular Diseases - blood ; Cholesterol ; Cholesterol, HDL - blood ; Disorders of blood lipids. Hyperlipoproteinemia ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Heart attacks ; Humans ; Longitudinal Studies ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Multivariate Analysis ; Peripheral Arterial Disease - blood ; Proportional Hazards Models ; Risk Factors ; Treatment Outcome ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2014-05, Vol.80 (5), p.662-670</ispartof><rights>2013 John Wiley & Sons Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2013 John Wiley & Sons Ltd.</rights><rights>Copyright © 2014 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4212-c9e40bf1ef0c24a20e817a282611855e26e2f2c9b6dfc5fdb104cae00aaa4dc73</citedby><cites>FETCH-LOGICAL-c4212-c9e40bf1ef0c24a20e817a282611855e26e2f2c9b6dfc5fdb104cae00aaa4dc73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28393015$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23550894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Araujo, Andre B.</creatorcontrib><creatorcontrib>Chiu, Gretchen R.</creatorcontrib><creatorcontrib>Christian, Jennifer B.</creatorcontrib><creatorcontrib>Kim, Hae Young</creatorcontrib><creatorcontrib>Evans, William J.</creatorcontrib><creatorcontrib>Clark, Richard V.</creatorcontrib><title>Longitudinal changes in high-density lipoprotein cholesterol and cardiovascular events in older adults</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol</addtitle><description>Summary
Objective
While low high‐density lipoprotein cholesterol (HDL‐C) is associated with increased risk of cardiovascular (CV) events, there are limited data evaluating the association of longitudinal change in HDL‐C with CV event risk in older populations. The aim of this study was to examine the association between within‐subject changes in HDL‐C levels and CV events in an older population.
Design
Observational cohort study.
Patients
1293 men and 1422 women age ≥50 years, with ≥2 consecutive HDL measurements, and no prior CVD as part of Framingham Offspring Study.
Measurements
A clinical CV event was defined as the first occurrence of any of the following: coronary heart disease (coronary death, myocardial infarction, coronary insufficiency and angina), cerebrovascular event, peripheral artery disease or heart failure.
Results
Median total follow‐up time across subjects was 9·6 years. Change in HDL‐C was evaluated as between‐exam (approximately 3·5 years) percentage change in HDL‐C, categorized as ≥10% decrease, <10% change (stable) and ≥10% increase. Crude and adjusted sex‐specific Cox hazards regression models with change in HDL‐C as a time‐dependent covariate quantified the association with CV events. Mean baseline age of the analysis sample was 53 years. There were 233 and 111 CV events among men and women, respectively. Change in HDL‐C was not significantly associated with CVD incidence in men or women, without or with adjustment for confounders including baseline HDL‐C or use of relevant medications.
Conclusion
In conclusion, relatively short‐term (3·5 years) changes in HDL‐C levels do not affect CV events in men and women.</description><subject>Aged</subject><subject>Aging</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cholesterol</subject><subject>Cholesterol, HDL - blood</subject><subject>Disorders of blood lipids. Hyperlipoproteinemia</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Peripheral Arterial Disease - blood</subject><subject>Proportional Hazards Models</subject><subject>Risk Factors</subject><subject>Treatment Outcome</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp1kc1uEzEURi0EoqGw4AXQSAipLKa1Pf6ZWULUBqSoZAFiaTn2ncTFsVN7pjRvj9OkRULCGy987nc_HSP0luBzUs6FgXBOKCX0GZqQRvCaUsGfowluMK6xEOwEvcr5BmPMWyxfohPacI7bjk1QP49h5YbRuqB9ZdY6rCBXLlRrt1rXFkJ2w67ybhu3KQ5QHsw6esgDpOgrHWxldLIu3ulsRq9TBXcQhoeE6C2kStvRD_k1etFrn-HN8T5FP64uv0-_1PNvs6_TT_PasFK_Nh0wvOwJ9NhQpimGlkhNWyoIaTkHKoD21HRLYXvDe7skmBkNGGutmTWyOUVnh9zS9nYsNdXGZQPe6wBxzIpwwhhtmdyj7_9Bb-KYioU9RQWVTEhaqI8HyqSYc4JebZPb6LRTBKu9fFXkqwf5hX13TByXG7BP5KPtAnw4AsWW9n3Swbj8l2ubrsGEF-7iwP12Hnb_36iml9ePq-vDhCs_c_80odMvJWQjufp5PVOfF7NusZBXat78Ada6qyE</recordid><startdate>201405</startdate><enddate>201405</enddate><creator>Araujo, Andre B.</creator><creator>Chiu, Gretchen R.</creator><creator>Christian, Jennifer B.</creator><creator>Kim, Hae Young</creator><creator>Evans, William J.</creator><creator>Clark, Richard V.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201405</creationdate><title>Longitudinal changes in high-density lipoprotein cholesterol and cardiovascular events in older adults</title><author>Araujo, Andre B. ; Chiu, Gretchen R. ; Christian, Jennifer B. ; Kim, Hae Young ; Evans, William J. ; Clark, Richard V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4212-c9e40bf1ef0c24a20e817a282611855e26e2f2c9b6dfc5fdb104cae00aaa4dc73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Aging</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cholesterol</topic><topic>Cholesterol, HDL - blood</topic><topic>Disorders of blood lipids. Hyperlipoproteinemia</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Peripheral Arterial Disease - blood</topic><topic>Proportional Hazards Models</topic><topic>Risk Factors</topic><topic>Treatment Outcome</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Araujo, Andre B.</creatorcontrib><creatorcontrib>Chiu, Gretchen R.</creatorcontrib><creatorcontrib>Christian, Jennifer B.</creatorcontrib><creatorcontrib>Kim, Hae Young</creatorcontrib><creatorcontrib>Evans, William J.</creatorcontrib><creatorcontrib>Clark, Richard V.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Araujo, Andre B.</au><au>Chiu, Gretchen R.</au><au>Christian, Jennifer B.</au><au>Kim, Hae Young</au><au>Evans, William J.</au><au>Clark, Richard V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal changes in high-density lipoprotein cholesterol and cardiovascular events in older adults</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol</addtitle><date>2014-05</date><risdate>2014</risdate><volume>80</volume><issue>5</issue><spage>662</spage><epage>670</epage><pages>662-670</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Objective
While low high‐density lipoprotein cholesterol (HDL‐C) is associated with increased risk of cardiovascular (CV) events, there are limited data evaluating the association of longitudinal change in HDL‐C with CV event risk in older populations. The aim of this study was to examine the association between within‐subject changes in HDL‐C levels and CV events in an older population.
Design
Observational cohort study.
Patients
1293 men and 1422 women age ≥50 years, with ≥2 consecutive HDL measurements, and no prior CVD as part of Framingham Offspring Study.
Measurements
A clinical CV event was defined as the first occurrence of any of the following: coronary heart disease (coronary death, myocardial infarction, coronary insufficiency and angina), cerebrovascular event, peripheral artery disease or heart failure.
Results
Median total follow‐up time across subjects was 9·6 years. Change in HDL‐C was evaluated as between‐exam (approximately 3·5 years) percentage change in HDL‐C, categorized as ≥10% decrease, <10% change (stable) and ≥10% increase. Crude and adjusted sex‐specific Cox hazards regression models with change in HDL‐C as a time‐dependent covariate quantified the association with CV events. Mean baseline age of the analysis sample was 53 years. There were 233 and 111 CV events among men and women, respectively. Change in HDL‐C was not significantly associated with CVD incidence in men or women, without or with adjustment for confounders including baseline HDL‐C or use of relevant medications.
Conclusion
In conclusion, relatively short‐term (3·5 years) changes in HDL‐C levels do not affect CV events in men and women.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><pmid>23550894</pmid><doi>10.1111/cen.12212</doi><tpages>9</tpages></addata></record> |
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| ispartof | Clinical endocrinology (Oxford), 2014-05, Vol.80 (5), p.662-670 |
| issn | 0300-0664 1365-2265 |
| language | eng |
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| source | Wiley:Jisc Collections:Wiley Read and Publish Open Access 2024-2025 (reading list) |
| subjects | Aged Aging Biological and medical sciences Cardiovascular disease Cardiovascular Diseases - blood Cholesterol Cholesterol, HDL - blood Disorders of blood lipids. Hyperlipoproteinemia Endocrinopathies Female Fundamental and applied biological sciences. Psychology Heart attacks Humans Longitudinal Studies Male Medical sciences Metabolic diseases Middle Aged Multivariate Analysis Peripheral Arterial Disease - blood Proportional Hazards Models Risk Factors Treatment Outcome Vertebrates: endocrinology |
| title | Longitudinal changes in high-density lipoprotein cholesterol and cardiovascular events in older adults |
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