Prognostic value of culprit site neutrophils in acute coronary syndrome

• Published in: European journal of clinical investigation 2014-03, Vol.44 (3), p.257-265
• Main Authors: Distelmaier, Klaus, Winter, Max-Paul, Dragschitz, Florian, Redwan, Bassam, Mangold, Andreas, Gleiss, Andreas, Perkmann, Thomas, Maurer, Gerald, Adlbrecht, Christopher, Lang, Irene M.
• Format: Article
• Language: English
• Subjects: Acute coronary syndrome; Acute Coronary Syndrome - mortality; Acute Coronary Syndrome - pathology; Aged; Female; Follow-Up Studies; Humans; Leukocyte Count; Male; Middle Aged; Myocardial Infarction - mortality; Myocardial Infarction - pathology; neutrophils; Neutrophils - pathology; Percutaneous Coronary Intervention; Prognosis; Prospective Studies; Thrombectomy; Thrombosis - mortality; Thrombosis - pathology
• ISSN: 0014-2972; 1365-2362
• DOI: 10.1111/eci.12228

Background Recent data suggest that acute coronary syndromes (ACS) and acute myocardial infarction (AMI) are characterized by an inflammatory subset of thrombosis. We have previously described the accumulation of neutrophils at the coronary culprit lesion site. In this work, we assessed the prognostic value of culprit site (CS) neutrophil accumulation on long‐term mortality in patients with AMI. Materials and methods In this prospective study, 417 AMI patients were enrolled after thrombectomy during primary percutaneous coronary intervention. The optimal cut‐off for CS neutrophil accumulation for predicting 4‐year all‐cause mortality was calculated using time‐dependent receiver operator characteristic curve analyses. Results The median follow‐up time was 39 months interquartile range (IQR 21·4–54·6 months) corresponding to 1217 patient years of follow‐up. The cut‐off for CS neutrophil accumulation (difference between culprit neutrophil counts and systemic neutrophil counts) was 0·25 Giga/l. CS neutrophil accumulation occurred in 195 patients (47%) and was independently associated with mortality (hazard ratio 1·88 (95%CI 1·02–3·41, P = 0·043)). In patients with CS neutrophil accumulation, 1‐year mortality (10·8% vs. 7·2%) and 4‐year mortality (19·8% vs. 10·4%) were markedly increased compared with patients without local neutrophil accumulation. Concordance index for CS neutrophil accumulation and mortality was 0·64 (95% CI 0·51–0·77; P = 0·035). Patients with CS neutrophil accumulation had significantly more often nonobstructive lesions compared with patients without neutrophil accumulation (32·6% vs. 22·4%; P = 0·024). Conclusions Neutrophil accumulation at the coronary culprit lesion site is a strong and independent predictor of mortality in patients with ACS/AMI.