Bivalent human papillomavirus vaccine and the risk of fatigue syndromes in girls in the UK

Highlights • In 2008, human papillomavirus vaccine was introduced for girls in the UK. • The MHRA ran proactive enhanced pharmacovigilance from the start of the campaign. • There were reports of chronic fatigue syndrome in association with the vaccine. • Epidemiological methods were used to build on...

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Bibliographic Details
Published in:Vaccine 2013-10, Vol.31 (43), p.4961-4967
Main Authors: Donegan, Katherine, Beau-Lejdstrom, Raphaelle, King, Bridget, Seabroke, Suzie, Thomson, Andrew, Bryan, Philip
Format: Article
Language:English
Subjects:
Adolescent
Adult
Allergy and Immunology
Applied microbiology
Biological and medical sciences
Cancer
Child
Chronic fatigue syndrome
epidemiological studies
Fatigue
Fatigue Syndrome, Chronic - epidemiology
Female
Fundamental and applied biological sciences. Psychology
girls
health services
Human papillomavirus
Human papillomavirus vaccine
Humans
Immunization
Incidence
Male
Management planning
Microbiology
Miscellaneous
monitoring
Mortality
neoplasms
Papillomavirus Vaccines - administration & dosage
Papillomavirus Vaccines - adverse effects
planning
risk
Risk Assessment
Risk management
United Kingdom
vaccination
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Virology
Young Adult
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Description
Summary:Highlights • In 2008, human papillomavirus vaccine was introduced for girls in the UK. • The MHRA ran proactive enhanced pharmacovigilance from the start of the campaign. • There were reports of chronic fatigue syndrome in association with the vaccine. • Epidemiological methods were used to build on data from spontaneous reports. • No increased risk of CFS after HPV vaccination was found.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.08.024