Microdrop Printing of Hydrogel Bioinks into 3D Tissue-Like Geometries

An optimized 3D inkjet printing process is demonstrated for structuring alginate into a tissue‐like microvasculature capable of supporting physiological flow rates. Optimizing the reaction at the single‐droplet level enables wet hydrogel droplets to be stacked, thus overcoming their natural tendancy...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2012-01, Vol.24 (3), p.391-396
Main Authors: Pataky, Kris, Braschler, Thomas, Negro, Andrea, Renaud, Philippe, Lutolf, Matthias P., Brugger, Juergen
Format: Article
Language:English
Subjects:
Alginates - chemistry
Animals
biofabrication
Biomimetics - methods
capillaries
Collagen - chemistry
Gelatin - chemistry
Glucuronic Acid - chemistry
Hexuronic Acids - chemistry
Hydrodynamics
Hydrogels
Ink
inkjet printing
Mice
Microtechnology - methods
NIH 3T3 Cells
Printing - methods
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Summary:An optimized 3D inkjet printing process is demonstrated for structuring alginate into a tissue‐like microvasculature capable of supporting physiological flow rates. Optimizing the reaction at the single‐droplet level enables wet hydrogel droplets to be stacked, thus overcoming their natural tendancy to spread and coalesce. Live cells can be patterned using this process and it can be extended to a range of other hydrogels.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201102800