Evaluation of bacterial cellulose/hyaluronan nanocomposite biomaterials

• Published in: Carbohydrate polymers 2014-03, Vol.103, p.496-501
• Main Authors: Li, Ying, Qing, Shuang, Zhou, Jianhai, Yang, Guang
• Format: Article
• Language: English
• Subjects: Applied sciences; Bacteria; Bacterial cellulose; Biocompatible Materials - chemistry; Cellulose - biosynthesis; Cellulose - chemistry; Cellulose and derivatives; Exact sciences and technology; Gluconacetobacter xylinus - chemistry; Gluconacetobacter xylinus - metabolism; Hyaluronan; Hyaluronic Acid - chemistry; Nanocomposites; Nanocomposites - chemistry; Natural polymers; Physicochemistry of polymers; Starch and polysaccharides; Temperature; Wound dressing
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2013.12.059

•BC/HA films were obtained using a solution impregnation method, and the results showed that this method is highly effective to form composites with BC.•The BC/HA composites showed enhanced properties in weight loss, elongation at break and thermal stability compared to pure BC.•BC/HA films presented in this work possess superior comprehensive properties, which suggested that these novel BC/HA films could be applied potentially as wound dressing materials. Bacterial cellulose (BC) is useful in the biomedical field because of its unique structure and properties. The high nano-porosity of BC allows other materials to be incorporated and form reinforced composites. Here we describe the preparation and characterization of novel BC/hyaluronan (HA) nanocomposites with a 3-D network structure. BC/HA was obtained using a solution impregnation method. Elemental and ATR-FTIR analyses showed that this method is highly effective to form composites with BC. Weight loss analysis showed that BC/HA have a lower water loss than BC at 37°C. The total surface area and pore volume of BC/HA films gradually decreased with the HA content, as followed by FE-SEM analysis. The elongation at break of BC/HA films gradually increased as the HA content increased. Thermogravimetric analysis showed that the weight loss for the BC/HA composites were lower than for pure BC between 250 and 350°C. The results of weight loss, elongation at break and thermal stability suggested that these novel BC/HA films could be applied potentially as wound dressing materials.