Replication of results of a genome-wide association study on lung cancer survival in a Korean population

Recently, a genome-wide association study (GWAS) identified single nucleotide polymorphisms (SNPs) that may influence the prognosis of early-stage non-small cell lung cancer (NSCLC) in Caucasians. We attempted to replicate the impact of genetic variants identified in the GWAS on lung cancer survival...

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Bibliographic Details
Published in:Cancer genetics 2014-01, Vol.207 (1), p.35-39.e2
Main Authors: Yoo, Seung Soo, Hong, Mi Jeong, Jeon, Hyo-Sung, Lee, Won Kee, Lee, Shin Yup, Lee, Jaehee, Cha, Seung Ick, Kim, Chang Ho, Lee, Eungbae, Park, Jae Yong
Format: Article
Language:English
Subjects:
Aged
Alleles
Asian Continental Ancestry Group - genetics
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Hematology, Oncology and Palliative Medicine
Humans
Lung Neoplasms - ethnology
Lung Neoplasms - genetics
Lung Neoplasms - mortality
Male
Medical Education
Middle Aged
Models, Genetic
non-small cell lung cancer
polymorphism
Polymorphism, Single Nucleotide
Prognosis
Proportional Hazards Models
Republic of Korea
Sequence Analysis, DNA
survival
Survival Analysis
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Summary:Recently, a genome-wide association study (GWAS) identified single nucleotide polymorphisms (SNPs) that may influence the prognosis of early-stage non-small cell lung cancer (NSCLC) in Caucasians. We attempted to replicate the impact of genetic variants identified in the GWAS on lung cancer survival in a Korean population. A total of 363 patients with surgically resected NSCLCs were enrolled, and 12 SNPs were genotyped using the SEQUENOM MassARRAY iPLEX assay, TaqMan assay, or a polymerase chain reaction–restriction fragment length polymorphism analysis. The association between genotypes and overall survival (OS) was analyzed. Among the 12 SNPs, the rs6034368T>C was associated with OS. Patients with the rs6034368C allele showed a better OS than the patients with the rs6034368T allele (adjusted hazard ratio = 0.72, confidence interval = 0.56–0.93, P = 0.01). The rs12446308A>G had an effect on OS, but it was marginally significant (under a codominant model, adjusted hazard ratio = 1.85, confidence interval = 0.98–3.47, P = 0.06). We identified that the rs6034368T>C was associated with survival in early-stage NSCLC in a Korean population.
ISSN:2210-7762
2210-7770
DOI:10.1016/j.cancergen.2013.12.002