Intravenous Salt Supplementation With Low-Dose Furosemide for Treatment of Acute Decompensated Heart Failure

Abstract Background Theoretically, salt supplementation should promote diuresis through increasing the glomerular filtration rate (GFR) during treatment of acute decompensated heart failure (ADHF) even with low-dose furosemide; however, there is little evidence to support this idea. Methods and Resu...

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Bibliographic Details
Published in:Journal of cardiac failure 2014-05, Vol.20 (5), p.295-301
Main Authors: Okuhara, Yoshitaka, MD, Hirotani, Shinichi, MD, PhD, Naito, Yoshiro, MD, PhD, Nakabo, Ayumi, MD, Iwasaku, Toshihiro, MD, Eguchi, Akiyo, MD, Morisawa, Daisuke, MD, Ando, Tomotaka, MD, Sawada, Hisashi, MD, Manabe, Eri, MD, Masuyama, Tohru, MD, PhD
Format: Article
Language:English
Subjects:
Acute Disease
Aged
Aged, 80 and over
Cardiovascular
Drug Therapy, Combination
Female
Furosemide - administration & dosage
glomerular filtration rate
Glomerular Filtration Rate - drug effects
Glomerular Filtration Rate - physiology
Glucose - administration & dosage
heart failure
Heart Failure - diagnosis
Heart Failure - drug therapy
Heart Failure - physiopathology
Humans
Infusions, Intravenous
loop diuretics
Male
Middle Aged
Prospective Studies
Saline Solution, Hypertonic
Salt restriction
Sodium Chloride - administration & dosage
Treatment Outcome
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Summary:Abstract Background Theoretically, salt supplementation should promote diuresis through increasing the glomerular filtration rate (GFR) during treatment of acute decompensated heart failure (ADHF) even with low-dose furosemide; however, there is little evidence to support this idea. Methods and Results This was a prospective, randomized, open-label, controlled trial that compared the diuretic effectiveness of salt infusion with that of glucose infusion supplemented with low-dose furosemide in 44 consecutive patients with ADHF. Patients were randomly administered 1.7% hypertonic saline solution supplemented with 40 mg furosemide (salt infusion group) or glucose supplemented with 40 mg furosemide (glucose infusion group). Our major end points were 24-hour urinary volume and GFR. Urinary volume was greater in the salt infusion group than in the glucose infusion group (2,701 ± 920 vs 1,777 ± 797 mL; P  
ISSN:1071-9164
1532-8414
DOI:10.1016/j.cardfail.2014.01.012